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==Protein environment affects the water-tryptophan binding mode. Molecular dynamics simulations of Engrailed homeodomain mutants==
==Protein environment affects the water-tryptophan binding mode. Molecular dynamics simulations of Engrailed homeodomain mutants==
<StructureSection load='6fvc' size='340' side='right'caption='[[6fvc]], [[NMR_Ensembles_of_Models | 3 NMR models]]' scene=''>
<StructureSection load='6fvc' size='340' side='right'caption='[[6fvc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fvc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FVC FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FVC FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">en, CG9015 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvc OCA], [http://pdbe.org/6fvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fvc RCSB], [http://www.ebi.ac.uk/pdbsum/6fvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvc OCA], [https://pdbe.org/6fvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fvc RCSB], [https://www.ebi.ac.uk/pdbsum/6fvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HMEN_DROME HMEN_DROME]] This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.  
[https://www.uniprot.org/uniprot/HMEN_DROME HMEN_DROME] This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jansen, S]]
[[Category: Jansen S]]
[[Category: Kozelka, J]]
[[Category: Kozelka J]]
[[Category: Srb, P]]
[[Category: Srb P]]
[[Category: Trosanova, Z]]
[[Category: Trosanova Z]]
[[Category: Zachrdla, M]]
[[Category: Zachrdla M]]
[[Category: Zidek, L]]
[[Category: Zidek L]]
[[Category: Dna]]
[[Category: Dna binding protein]]
[[Category: Engrailed homeodomain]]
[[Category: K52e mutation]]

Latest revision as of 06:05, 19 June 2024

Protein environment affects the water-tryptophan binding mode. Molecular dynamics simulations of Engrailed homeodomain mutants

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