4uf3: Difference between revisions

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<StructureSection load='4uf3' size='340' side='right'caption='[[4uf3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4uf3' size='340' side='right'caption='[[4uf3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deerpox_virus Deerpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UF3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uf3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deerpox_virus_W-1170-84 Deerpox virus W-1170-84] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UF3 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uf1|4uf1]], [[4uf2|4uf2]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf3 OCA], [http://pdbe.org/4uf3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uf3 RCSB], [http://www.ebi.ac.uk/pdbsum/4uf3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uf3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf3 OCA], [https://pdbe.org/4uf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uf3 RCSB], [https://www.ebi.ac.uk/pdbsum/4uf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uf3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
[https://www.uniprot.org/uniprot/DPV22_DPV83 DPV22_DPV83] Plays a role in the inhibition of host apoptosis by sequestering and inactivating several proapoptotic BCL-2 proteins, including BAK1 and BAX. Prevents the conformational activation of both of them.<ref>PMID:21159883</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deerpox virus]]
[[Category: Deerpox virus W-1170-84]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Burton, D R]]
[[Category: Burton DR]]
[[Category: Kvansakul, M]]
[[Category: Kvansakul M]]
[[Category: Apoptosis]]
[[Category: Bcl-2]]
[[Category: Bim bh3]]
[[Category: Dpv022]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4uf3"