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<StructureSection load='4url' size='340' side='right'caption='[[4url]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4url' size='340' side='right'caption='[[4url]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4url]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4URL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4URL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4url]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4URL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4URL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XAM:(1R,4AS,5S,6S,8AR)-5-{[(5S)-1-(3-O-ACETYL-4-O-CARBAMOYL-6-DEOXY-2-O-METHYL-ALPHA-L-TALOPYRANOSYL)-4-HYDROXY-2-OXO-5-(PROPAN-2-YL)-2,5-DIHYDRO-1H-PYRROL-3-YL]CARBONYL}-6-METHYL-4-METHYLIDENE-1,2,3,4,4A,5,6,8A-OCTAHYDRONAPHTHALEN-1-YL+2,6-DIDEOXY-3-C-[(1S)-1-{[(3,4-DICHLORO-5-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}ETHYL]-BETA-D-RIBO-HEXOPYRANOSIDE'>XAM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4urm|4urm]], [[4urn|4urn]], [[4uro|4uro]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XAM:(1R,4AS,5S,6S,8AR)-5-{[(5S)-1-(3-O-ACETYL-4-O-CARBAMOYL-6-DEOXY-2-O-METHYL-ALPHA-L-TALOPYRANOSYL)-4-HYDROXY-2-OXO-5-(PROPAN-2-YL)-2,5-DIHYDRO-1H-PYRROL-3-YL]CARBONYL}-6-METHYL-4-METHYLIDENE-1,2,3,4,4A,5,6,8A-OCTAHYDRONAPHTHALEN-1-YL+2,6-DIDEOXY-3-C-[(1S)-1-{[(3,4-DICHLORO-5-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}ETHYL]-BETA-D-RIBO-HEXOPYRANOSIDE'>XAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4url FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4url OCA], [http://pdbe.org/4url PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4url RCSB], [http://www.ebi.ac.uk/pdbsum/4url PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4url ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4url FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4url OCA], [https://pdbe.org/4url PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4url RCSB], [https://www.ebi.ac.uk/pdbsum/4url PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4url ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/X5EN43_STAAU X5EN43_STAAU]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity).[HAMAP-Rule:MF_00939]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Topoisomerase|Topoisomerase]]
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fukuda, Y]]
[[Category: Staphylococcus aureus]]
[[Category: Kishii, R]]
[[Category: Fukuda Y]]
[[Category: Lu, J]]
[[Category: Kishii R]]
[[Category: Lumb, K J]]
[[Category: Lu J]]
[[Category: Patel, S]]
[[Category: Lumb KJ]]
[[Category: Sharma, N]]
[[Category: Patel S]]
[[Category: Singh, S B]]
[[Category: Sharma N]]
[[Category: Soisson, S]]
[[Category: Singh SB]]
[[Category: Takei, M]]
[[Category: Soisson S]]
[[Category: Antibiotic]]
[[Category: Takei M]]
[[Category: Gyrase]]
[[Category: Isomerase]]
[[Category: Kibdelomycin]]
[[Category: Natural product]]
[[Category: Topoisomerase iv]]
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