4uhv: Difference between revisions
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<StructureSection load='4uhv' size='340' side='right'caption='[[4uhv]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4uhv' size='340' side='right'caption='[[4uhv]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uhv]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4uhv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhv OCA], [https://pdbe.org/4uhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhv RCSB], [https://www.ebi.ac.uk/pdbsum/4uhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/VGR1A_PSEAE VGR1A_PSEAE] Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 (PubMed:26894531). Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity (PubMed:30177742).<ref>PMID:21325275</ref> <ref>PMID:24794869</ref> <ref>PMID:26894531</ref> <ref>PMID:30177742</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Pseudomonas aeruginosa PAO1]] | ||
[[Category: Davo-Siguero | [[Category: Davo-Siguero I]] | ||
[[Category: Medrano | [[Category: Medrano FJ]] | ||
[[Category: Romero | [[Category: Romero A]] | ||
[[Category: Ruiz | [[Category: Ruiz FM]] | ||
[[Category: Santillana | [[Category: Santillana E]] | ||
[[Category: Spinola-Amilibia | [[Category: Spinola-Amilibia M]] | ||
Latest revision as of 10:29, 10 January 2024
The structure of VgrG1, the needle tip of the bacterial Type VI Secretion System
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