Cyclin: Difference between revisions

(4 intermediate revisions by the same user not shown)

Line 4:

'''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs:

* '''CYCA''' is active in the S phase

* '''CYCA2''' regulates DNA replication and mitotic entry.<ref>PMID:33402344</ref>

* '''CYCB1''' is essential for the control of the cell cycle at the G2/M (mitosis) transition.

* '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.br />

* '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.

* '''CYCCCL1''' controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription <ref>PMID:8761664</ref>

* '''CYCD''' regulates the transition from G1 to S.<ref>PMID:15130482</ref>

* '''CYCE''' and its CDK partner are key regulators of DNA synthesis and of mitosis.<ref>PMID:11907280</ref>

* '''CYCF''' is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex<ref>PMID:28652210</ref>

* '''CYCH''' is highly expressed in ovarian cancer<ref>PMID:32694938</ref>

* '''CYCK''' and its CDK12 partner regulate the expression of DNA-damage response genes and thus protect cells from genomic instability.<ref>PMID:22012619</ref>

* '''CYCT''' and its CDK9 partner regulate gene expression.<ref>PMID:15276198</ref>

* '''Viral CYC''' could be involved in oncogenic events associated with the cyclin-encoding viruses.<ref>PMID:10815028</ref>

See also [[Intrinsically Disordered Protein]].

== Relevance ==

Line 26:

Line 30:

</StructureSection>

~~== 3D Structures of Cyclin ==~~

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

*CYCA2

**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human

**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor

**[[1fin]], [[5if1]] - hCYCA2 +CDK2

**[[1vyw]] - hCYCA2 C-terminal + hCDK2

**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P

**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide

**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor

**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor

**[[4fx3]] - hCYCA2 +CDK2 + inhibitor

**[[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCYCA2 C-terminal +CDK2 T160P + inhibitor

**[[2cjm]] - hCYCA2 +CDK2 T160P Y15P

**[[2cch]] - hCYCA2 +CDK2 T160P+ATP analog

**[[4i3z]], [[4ii5]] - hCYCA2 +CDK2 T160P+ADP + Mg

**[[2cci]] - hCYCA2 +CDK2 T160P+CDC homolog

**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1qmz]], [[3qhw]] - hCYCA2 +CDK2+peptide

**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27

**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse

*CYCA3

**[[1vin]] – CYCA3 - bovine

**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor

*CYCB1 or G2/mitotic-specific CYCB1

**[[2b9r]] – hCYCB1 (mutant)

**[[2jgz]] - hCYCB1 + CDK2

**[[6gu4]], [[6gu3]], [[6gu2]] – hCYCB1 + hCDK1 + inhibitor

**[[5hq0]], [[4yc3]], [[4y72]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2

**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor

*CYCC

**[[3rgf]], [[4g6l]] – hCYCC + CDK8

**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]] – hCYCC + CDK8 + inhibitor

*CYCD

**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] - hCYCD1 +CDK4 (mutant)

**[[6ei2]] – hCYCD2 + HLA + microglobulin

**[[3g33]] – hCYCD3 + CDK4

*CYCE

**[[1w98]] – hCYCE1 + CDK2 T160P

**[[5l2w]] – hCYCE1 + CDK2 + drug

*CYCH

**[[1kxu]], [[1jkw]] – hCYCH

*CYCK

**[[2i53]] – hCYCK N-terminal

**[[4un0]] - hCYCK + CDK12 T160P

**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP

**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP

**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor

*CYCT

**[[3blh]] - hCYCT1 +CDK9

**[[3blq]] - hCYCT1 +CDK9+ATP

**[[4imy]], [[4or5]], [[4ogr]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4

**[[5l1z]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + RNA

**[[6cyt]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + TAT + RNA

**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9

**[[3blr]] - hCYCT1 +CDK9+inhibitor

**[[6gzh]] - hCYCT1 TPO160 +CDK9+inhibitor

**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor

**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT

**[[2w2h]] - CYCT1 +protein TAT + RNA – horse

**[[2ivx]] – hCYCT2 (mutant)

*CYC

**[[2pk9]] – yCYC PHO80 +CDK PHO85 – yeast

**[[2pmi]] - yCYC PHO80 +CDK PHO85+ATPgS

*Viral CYC

**[[2euf]], [[2f2c]], [[2xo2]], [[1jow]] – V-CYC+hCDK6 – Herpesvirus

**[[1bu2]] – V-CYC

**[[1xo2]] - V-CYC + hCDK6 + inhibitor

**[[1g3n]] - V-CYC +hCDK6+CDK6 inhibitor

**[[1f5q]] - V-CYC g +hCDK2

}}

== References ==

[[Category:Topic Page]]

@@ Line 4: / Line 4: @@
 '''Cyclin''' (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle.  The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle.  Among the CYCs:<br />
 * '''CYCA''' is active in the S phase<br />
+* '''CYCA2''' regulates DNA replication and mitotic entry.<ref>PMID:33402344</ref><br />
 * '''CYCB1''' is essential for the control of the cell cycle at the G2/M (mitosis) transition.<br />
-* '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.br />
+* '''CYCC''' is active in the G0/G1 phase transition<ref>PMID:12910258</ref>.<br />
+* '''CYCCCL1''' controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription <ref>PMID:8761664</ref><br />
 * '''CYCD''' regulates the transition from G1 to S.<ref>PMID:15130482</ref><br />
 * '''CYCE''' and its CDK partner are key regulators of DNA synthesis and of mitosis.<ref>PMID:11907280</ref><br />
+* '''CYCF''' is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex<ref>PMID:28652210</ref><br />
+* '''CYCH''' is highly expressed in ovarian cancer<ref>PMID:32694938</ref><br />
 * '''CYCK''' and its CDK12 partner regulate the expression of DNA-damage response genes and thus protect cells from genomic instability.<ref>PMID:22012619</ref><br />
 * '''CYCT''' and its CDK9 partner regulate gene expression.<ref>PMID:15276198</ref><br />
 * '''Viral CYC''' could be involved in oncogenic events associated with the cyclin-encoding viruses.<ref>PMID:10815028</ref><br />
- See also [[Intrinsically Disordered Protein]].
+See also [[Intrinsically Disordered Protein]].
 == Relevance ==
@@ Line 26: / Line 30: @@
 </StructureSection>
-== 3D Structures of Cyclin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CYCA2
-**[[3my5]], [[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[3dog]], [[3ddp]], [[3ddq]], [[3bht]], [[2v22]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2bpm]], [[2c4g]], [[1fvv]], [[2c6t]] – hCYCA2 +CDK2+inhibitor - human<br />
-**[[3bhu]], [[3bhv]], [[2uzd]], [[2uzb]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1p5e]], [[1pkd]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[4cfx]], [[4cfv]], [[4cfu]], [[4cfm]], [[5nev]], [[5nev]], [[5lmk]], [[5cyi]] - hCYCA2 +CDK2 T160P+inhibitor<br />
-**[[1fin]], [[5if1]] - hCYCA2 +CDK2<br />
-**[[1vyw]] - hCYCA2 C-terminal + hCDK2<br />
-**[[1jst]], [[3tnw]] - hCYCA2 +CDK2 T160P<br />
-**[[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]] - hCYCA2 +CDK2 T160P+peptide<br />
-**[[4bck]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfn]], [[4cfw]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6gub]] - hCYCA2 +CDK2 T160P + inhibitor<br />
-**[[6ath]] - hCYCA2 +CDK2 T160P + cyclin-dependent kinase inhibitor<br />
-**[[4fx3]] - hCYCA2 +CDK2 + inhibitor<br />
-**[[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCYCA2 C-terminal +CDK2 T160P + inhibitor<br />
-**[[2cjm]] - hCYCA2 +CDK2 T160P Y15P<br />
-**[[2cch]] - hCYCA2 +CDK2 T160P+ATP analog<br />
-**[[4i3z]], [[4ii5]] - hCYCA2 +CDK2 T160P+ADP + Mg<br />
-**[[2cci]] - hCYCA2 +CDK2 T160P+CDC homolog<br />
-**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1qmz]], [[3qhw]] - hCYCA2 +CDK2+peptide<br />
-**[[1jsu]] - hCYCA2 +CDK2 (mutant)+P27<br />
-**[[3qhr]], [[3khw]] - CYCA2 + P33 protein kinase + CDK2 peptide – mouse
-*CYCA3
-**[[1vin]] – CYCA3 - bovine<br />
-**[[1e9h]] – hCYCA3 +CDK2 T160P+inhibitor<br />
-*CYCB1 or G2/mitotic-specific CYCB1
-**[[2b9r]] – hCYCB1 (mutant)<br />
-**[[2jgz]] - hCYCB1 + CDK2<br />
-**[[6gu4]], [[6gu3]], [[6gu2]] – hCYCB1 + hCDK1 + inhibitor<br />
-**[[5hq0]], [[4yc3]], [[4y72]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2<br />
-**[[5lqf]] – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor<br />
-*CYCC
-**[[3rgf]], [[4g6l]] – hCYCC + CDK8<br />
-**[[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4f7s]], [[5idp]], [[5idn]], [[5icp]], [[5i5z]], [[5hvy]], [[5hnb]], [[5hbj]], [[5hbh]], [[5hbe]], [[5fgk]], [[5cei]], [[5bnj]], [[5xqx]], [[5xs2]]  – hCYCC + CDK8 + inhibitor<br />
-*CYCD
-**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] - hCYCD1 +CDK4 (mutant)<br />
-**[[6ei2]] – hCYCD2 + HLA + microglobulin<br />
-**[[3g33]] – hCYCD3 + CDK4
-*CYCE
-**[[1w98]] – hCYCE1 + CDK2 T160P<br />
-**[[5l2w]] – hCYCE1 + CDK2 + drug<br />
-*CYCH
-**[[1kxu]], [[1jkw]] – hCYCH
-*CYCK
-**[[2i53]] – hCYCK N-terminal<br />
-**[[4un0]] - hCYCK + CDK12 T160P<br />
-**[[4cxa]] - hCYCK + CDK12 T160P + AMPPNP<br />
-**[[5efq]], [[4nst]] - hCYCK + CDK13 T160P + ADP<br />
-**[[4un0]], [[5acb]], [[6b3e]], [[6ckx]] - hCYCK +CDK12 T160P + inhibitor<br />
-*CYCT
-**[[3blh]] - hCYCT1 +CDK9<br />
-**[[3blq]] - hCYCT1 +CDK9+ATP<br />
-**[[4imy]], [[4or5]], [[4ogr]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4<br />
-**[[5l1z]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + RNA<br />
-**[[6cyt]] - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + TAT + RNA<br />
-**[[3lq5]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCYCT1 (mutant)+CDK9<br />
-**[[3blr]] - hCYCT1 +CDK9+inhibitor<br />
-**[[6gzh]] - hCYCT1 TPO160 +CDK9+inhibitor<br />
-**[[3my1]], [[4ec8]], [[4ec9]] - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor<br />
-**[[3mi9]], [[3mia]] - hCYCT1 +CDK9+protein TAT<br />
-**[[2w2h]] - CYCT1 +protein TAT + RNA – horse<br />
-**[[2ivx]] – hCYCT2 (mutant)
-*CYC
-**[[2pk9]] – yCYC PHO80 +CDK PHO85 – yeast<br />
-**[[2pmi]] - yCYC PHO80 +CDK PHO85+ATPgS
-*Viral CYC
-**[[2euf]], [[2f2c]], [[2xo2]], [[1jow]] – V-CYC+hCDK6 – Herpesvirus<br />
-**[[1bu2]] – V-CYC<br />
-**[[1xo2]] - V-CYC + hCDK6 + inhibitor<br />
-**[[1g3n]] - V-CYC +hCDK6+CDK6 inhibitor<br />
-**[[1f5q]] - V-CYC g +hCDK2
- }}
 == References ==
 <references/>
 [[Category:Topic Page]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools