6owz: Difference between revisions
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New page: '''Unreleased structure''' The entry 6owz is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Spy H96L:Im7 L19pI-Phe complex; multiple anomalous datasets contained herein for element identification== | |||
<StructureSection load='6owz' size='340' side='right'caption='[[6owz]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6owz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OWZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6owz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6owz OCA], [https://pdbe.org/6owz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6owz RCSB], [https://www.ebi.ac.uk/pdbsum/6owz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6owz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPY_ECOLI SPY_ECOLI] An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface (PubMed:21317898, PubMed:24497545). Substrate protein folds while it is bound to chaperone (PubMed:26619265). Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates) (PubMed:24497545). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity (PubMed:21317898). Overexpression enhances the stability of otherwise unstable periplasmic proteins (PubMed:21317898).<ref>PMID:21317898</ref> <ref>PMID:24497545</ref> <ref>PMID:26619265</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Large Structures]] | |||
[[Category: Bardwell JCA]] | |||
[[Category: Duman R]] | |||
[[Category: El Omari K]] | |||
[[Category: Horowitz S]] | |||
[[Category: Mykhaylyk V]] | |||
[[Category: Rocchio S]] | |||
[[Category: Wagner A]] | |||
[[Category: Yan Z]] | |||
Latest revision as of 07:18, 11 October 2023
Spy H96L:Im7 L19pI-Phe complex; multiple anomalous datasets contained herein for element identification
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