6rqs: Difference between revisions
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The | ==RW16 peptide== | ||
<StructureSection load='6rqs' size='340' side='right'caption='[[6rqs]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RQS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=KFB:5-Aminovaleric+Acid'>KFB</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqs OCA], [https://pdbe.org/6rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rqs RCSB], [https://www.ebi.ac.uk/pdbsum/6rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqs ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cell-penetrating peptides (CPPs) are short peptides that can translocate and transport cargoes into the intracellular milieu by crossing biological membranes. The mode of interaction and internalization of cell-penetrating peptides has long been controversial. While their interaction with anionic membranes is quite well understood, the insertion and behavior of CPPs in zwitterionic membranes, a major lipid component of eukaryotic cell membranes, is poorly studied. Herein, we investigated the membrane insertion of RW16 into zwitterionic membranes, a versatile CPP that also presents antibacterial and antitumor activities. Using complementary approaches, including NMR spectroscopy, fluorescence spectroscopy, circular dichroism, and molecular dynamic simulations, we determined the high-resolution structure of RW16 and measured its membrane insertion and orientation properties into zwitterionic membranes. Altogether, these results contribute to explaining the versatile properties of this peptide toward zwitterionic lipids. | |||
Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.,Jobin ML, Vamparys L, Deniau R, Grelard A, Mackereth CD, Fuchs PFJ, Alves ID Int J Mol Sci. 2019 Sep 9;20(18). pii: ijms20184441. doi: 10.3390/ijms20184441. PMID:31505894<ref>PMID:31505894</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Alves | <div class="pdbe-citations 6rqs" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Alves I]] | |||
[[Category: Grelard A]] | |||
[[Category: Jobin M-L]] | |||
[[Category: Mackereth CD]] | |||
