6p2v: Difference between revisions

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New page: '''Unreleased structure''' The entry 6p2v is ON HOLD Authors: Andorfer, M.C., Sukumar, N., Lewis, J.C. Description: RebH Variant 10S, Tryptamine 5-halogenase [[Category: Unreleased Str...
 
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'''Unreleased structure'''


The entry 6p2v is ON HOLD
==RebH Variant 10S, Tryptamine 5-halogenase==
 
<StructureSection load='6p2v' size='340' side='right'caption='[[6p2v]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
Authors: Andorfer, M.C., Sukumar, N., Lewis, J.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6p2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lentzea_aerocolonigenes Lentzea aerocolonigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P2V FirstGlance]. <br>
Description: RebH Variant 10S, Tryptamine 5-halogenase
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.553&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
[[Category: Sukumar, N]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p2v OCA], [https://pdbe.org/6p2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p2v RCSB], [https://www.ebi.ac.uk/pdbsum/6p2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p2v ProSAT]</span></td></tr>
[[Category: Lewis, J.C]]
</table>
[[Category: Andorfer, M.C]]
== Function ==
[https://www.uniprot.org/uniprot/REBH_LENAE REBH_LENAE] Involved in the biosynthesis of the indolocarbazole antitumor agent rebeccamycin. Catalyzes the chlorination of tryptophan (Trp) at C7 position to yield 7-chlorotryptophan. The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobrominated Trp.<ref>PMID:11983340</ref> <ref>PMID:15743914</ref> <ref>PMID:17260957</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lentzea aerocolonigenes]]
[[Category: Andorfer MC]]
[[Category: Lewis JC]]
[[Category: Sukumar N]]
Retrieved from "https://proteopedia.org/6p2v"