6rsn: Difference between revisions

Latest revision as of 05:44, 21 November 2024

SOSEKI polymerising domain (SOK4 D85A mutant)

Structural highlights

6rsn is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:	MSE, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SOK4_ARATH SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization (PubMed:30737509). Positive regulator of auxin (indole-3-acetic acid, IAA) biosynthesis and signaling pathway leading to the modulation of seedling growth, plant and inflorescence development (PubMed:31207460). Negative regulator of stress responses (e.g. salinity and osmotic stress) (PubMed:31207460).^[1] ^[2]

Publication Abstract from PubMed

Cell polarity is fundamental for tissue morphogenesis in multicellular organisms. Plants and animals evolved multicellularity independently, and it is unknown whether their polarity systems are derived from a single-celled ancestor. Planar polarity in animals is conferred by Wnt signaling, an ancient signaling pathway transduced by Dishevelled, which assembles signalosomes by dynamic head-to-tail DIX domain polymerization. In contrast, polarity-determining pathways in plants are elusive. We recently discovered Arabidopsis SOSEKI proteins, which exhibit polar localization throughout development. Here, we identify SOSEKI as ancient polar proteins across land plants. Concentration-dependent polymerization via a bona fide DIX domain allows these to recruit ANGUSTIFOLIA to polar sites, similar to the polymerization-dependent recruitment of signaling effectors by Dishevelled. Cross-kingdom domain swaps reveal functional equivalence of animal and plant DIX domains. We trace DIX domains to unicellular eukaryotes and thus show that DIX-dependent polymerization is an ancient mechanism conserved between kingdoms and central to polarity proteins.

DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.,van Dop M, Fiedler M, Mutte S, de Keijzer J, Olijslager L, Albrecht C, Liao CY, Janson ME, Bienz M, Weijers D Cell. 2020 Feb 6;180(3):427-439.e12. doi: 10.1016/j.cell.2020.01.011. Epub 2020, Jan 30. PMID:32004461^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yoshida S, van der Schuren A, van Dop M, van Galen L, Saiga S, Adibi M, Möller B, Ten Hove CA, Marhavy P, Smith R, Friml J, Weijers D. A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis. Nat Plants. 2019 Feb;5(2):160-166. PMID:30737509 doi:10.1038/s41477-019-0363-6
↑ Shen L, Zhong T, Wang L, Zhang Q, Jin H, Xu M, Ye J. Characterization the role of a UFC homolog, AtAuxRP3, in the regulation of Arabidopsis seedling growth and stress response. J Plant Physiol. 2019 Sep;240:152990. PMID:31207460 doi:10.1016/j.jplph.2019.152990
↑ van Dop M, Fiedler M, Mutte S, de Keijzer J, Olijslager L, Albrecht C, Liao CY, Janson ME, Bienz M, Weijers D. DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes. Cell. 2020 Feb 6;180(3):427-439.e12. doi: 10.1016/j.cell.2020.01.011. Epub 2020, Jan 30. PMID:32004461 doi:https://dx.doi.org/10.1016/j.cell.2020.01.011

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OCA

[1] Yoshida S, van der Schuren A, van Dop M, van Galen L, Saiga S, Adibi M, Möller B, Ten Hove CA, Marhavy P, Smith R, Friml J, Weijers D. A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis. Nat Plants. 2019 Feb;5(2):160-166. PMID:30737509 doi:10.1038/s41477-019-0363-6

[2] Shen L, Zhong T, Wang L, Zhang Q, Jin H, Xu M, Ye J. Characterization the role of a UFC homolog, AtAuxRP3, in the regulation of Arabidopsis seedling growth and stress response. J Plant Physiol. 2019 Sep;240:152990. PMID:31207460 doi:10.1016/j.jplph.2019.152990

[3] van Dop M, Fiedler M, Mutte S, de Keijzer J, Olijslager L, Albrecht C, Liao CY, Janson ME, Bienz M, Weijers D. DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes. Cell. 2020 Feb 6;180(3):427-439.e12. doi: 10.1016/j.cell.2020.01.011. Epub 2020, Jan 30. PMID:32004461 doi:https://dx.doi.org/10.1016/j.cell.2020.01.011

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6rsn is ON HOLD
+==SOSEKI polymerising domain (SOK4 D85A mutant)==
+<StructureSection load='6rsn' size='340' side='right'caption='[[6rsn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSN FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rsn OCA], [https://pdbe.org/6rsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rsn RCSB], [https://www.ebi.ac.uk/pdbsum/6rsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rsn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SOK4_ARATH SOK4_ARATH] SOSEKI proteins (SOK1-5) locally interpret global polarity cues and can influence cell division orientation to coordinate cell polarization relative to body axes, probably by guiding ANGUSTIFOLIA (AN) polarized localization (PubMed:30737509). Positive regulator of auxin (indole-3-acetic acid, IAA) biosynthesis and signaling pathway leading to the modulation of seedling growth, plant and inflorescence development (PubMed:31207460). Negative regulator of stress responses (e.g. salinity and osmotic stress) (PubMed:31207460).<ref>PMID:30737509</ref> <ref>PMID:31207460</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cell polarity is fundamental for tissue morphogenesis in multicellular organisms. Plants and animals evolved multicellularity independently, and it is unknown whether their polarity systems are derived from a single-celled ancestor. Planar polarity in animals is conferred by Wnt signaling, an ancient signaling pathway transduced by Dishevelled, which assembles signalosomes by dynamic head-to-tail DIX domain polymerization. In contrast, polarity-determining pathways in plants are elusive. We recently discovered Arabidopsis SOSEKI proteins, which exhibit polar localization throughout development. Here, we identify SOSEKI as ancient polar proteins across land plants. Concentration-dependent polymerization via a bona fide DIX domain allows these to recruit ANGUSTIFOLIA to polar sites, similar to the polymerization-dependent recruitment of signaling effectors by Dishevelled. Cross-kingdom domain swaps reveal functional equivalence of animal and plant DIX domains. We trace DIX domains to unicellular eukaryotes and thus show that DIX-dependent polymerization is an ancient mechanism conserved between kingdoms and central to polarity proteins.
-Authors:
+DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.,van Dop M, Fiedler M, Mutte S, de Keijzer J, Olijslager L, Albrecht C, Liao CY, Janson ME, Bienz M, Weijers D Cell. 2020 Feb 6;180(3):427-439.e12. doi: 10.1016/j.cell.2020.01.011. Epub 2020, Jan 30. PMID:32004461<ref>PMID:32004461</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6rsn" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Large Structures]]
+[[Category: Bienz M]]
+[[Category: Fiedler M]]

6rsn: Difference between revisions

Latest revision as of 05:44, 21 November 2024

SOSEKI polymerising domain (SOK4 D85A mutant)

Structural highlights

Function

Publication Abstract from PubMed

References

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