6mju: Difference between revisions

<table><tr><td colspan='2'>[[6mju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJU FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUM:1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mju OCA], [https://pdbe.org/6mju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mju RCSB], [https://www.ebi.ac.uk/pdbsum/6mju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mju ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>  

 

[[Category: Homo sapiens]]

[[Category: Adura C]]

[[Category: Aida J]]

[[Category: Asano Y]]

[[Category: Gao P]]

[[Category: Glickman JF]]

[[Category: Gogakos T]]

[[Category: Hashizume S]]

[[Category: Imaeda T]]

[[Category: Jennings AJ]]

[[Category: Kamei T]]

[[Category: Kuroita T]]

[[Category: Kuryavyi V]]

[[Category: Lama L]]

[[Category: Meinke P]]

[[Category: Michinom M]]

[[Category: Miller M]]

[[Category: Okamoto R]]

[[Category: Patel DJ]]

[[Category: Ramos-Espiritu L]]

[[Category: Stamford A]]

[[Category: Steinberg JI]]

[[Category: Tomita D]]

[[Category: Tuschl T]]

[[Category: Xie W]]