6mjw: Difference between revisions
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<StructureSection load='6mjw' size='340' side='right'caption='[[6mjw]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='6mjw' size='340' side='right'caption='[[6mjw]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6mjw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJW OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6mjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JUJ:1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUJ:1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjw OCA], [https://pdbe.org/6mjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjw RCSB], [https://www.ebi.ac.uk/pdbsum/6mjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
==See Also== | |||
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Adura | [[Category: Adura C]] | ||
[[Category: Aida | [[Category: Aida J]] | ||
[[Category: Asano | [[Category: Asano Y]] | ||
[[Category: Gao | [[Category: Gao P]] | ||
[[Category: Glickman | [[Category: Glickman JF]] | ||
[[Category: Gogakos | [[Category: Gogakos T]] | ||
[[Category: Hashizume | [[Category: Hashizume S]] | ||
[[Category: Imaeda | [[Category: Imaeda T]] | ||
[[Category: Jennings | [[Category: Jennings AJ]] | ||
[[Category: Kamei | [[Category: Kamei T]] | ||
[[Category: Kuroita | [[Category: Kuroita T]] | ||
[[Category: Kuryavyi | [[Category: Kuryavyi V]] | ||
[[Category: Lama | [[Category: Lama L]] | ||
[[Category: Meinke | [[Category: Meinke P]] | ||
[[Category: Michinom | [[Category: Michinom M]] | ||
[[Category: Miller | [[Category: Miller M]] | ||
[[Category: Okamoto | [[Category: Okamoto R]] | ||
[[Category: Patel | [[Category: Patel DJ]] | ||
[[Category: Ramos-Espiritu | [[Category: Ramos-Espiritu L]] | ||
[[Category: Stamford | [[Category: Stamford A]] | ||
[[Category: Steinberg | [[Category: Steinberg JI]] | ||
[[Category: Tomita | [[Category: Tomita D]] | ||
[[Category: Tuschl | [[Category: Tuschl T]] | ||
[[Category: Xie | [[Category: Xie W]] | ||
Latest revision as of 14:43, 13 March 2024
human cGAS catalytic domain bound with the inhibitor G150
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