6rim: Difference between revisions
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<StructureSection load='6rim' size='340' side='right'caption='[[6rim]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='6rim' size='340' side='right'caption='[[6rim]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6rim]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIM OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6rim]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Weissella_oryzae Weissella oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RIM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rim OCA], [https://pdbe.org/6rim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rim RCSB], [https://www.ebi.ac.uk/pdbsum/6rim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rim ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BXWO_WEIOS BXWO_WEIOS] When overexpressed the N-terminus (residues 1-476) cleaves rat synaptobrevin-2/VAMP2 between '89-Trp-|-Trp-90' in vitro. This releases the cytoplasmic domain of VAMP2 from the synaptic vesicle membrane, which would prevent the assembly of the trans-SNARE complex on the membrane and thus prevent vesicle-target membrane fusion and neurotransmitter release (PubMed:27443638).<ref>PMID:27443638</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Weissella oryzae]] | ||
[[Category: | [[Category: Kosenina S]] | ||
[[Category: | [[Category: Masuyer G]] | ||
[[Category: | [[Category: Stenmark P]] | ||
Latest revision as of 10:25, 23 October 2024
Crystal structure of the catalytic domain of the Weissela oryzae botulinum like toxin
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