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==Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor==
==Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor==
<StructureSection load='6nk7' size='340' side='right'caption='[[6nk7]], [[Resolution|resolution]] 4.99&Aring;' scene=''>
<SX load='6nk7' size='340' side='right' viewer='molstar' caption='[[6nk7]], [[Resolution|resolution]] 4.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nk7]] is a 17 chain structure with sequence from [http://en.wikipedia.org/wiki/Chikv Chikv] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NK7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nk7]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Chikungunya_virus Chikungunya virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NK7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.99&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHIKVgp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37124 CHIKV]), Mxra8, Asp3, Dicam ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Togavirin Togavirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.90 3.4.21.90] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk7 OCA], [https://pdbe.org/6nk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nk7 RCSB], [https://www.ebi.ac.uk/pdbsum/6nk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk7 OCA], [http://pdbe.org/6nk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6nk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref> 
[https://www.uniprot.org/uniprot/Q88628_CHIKV Q88628_CHIKV]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6nk7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6nk7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Chikv]]
[[Category: Chikungunya virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Togavirin]]
[[Category: Basore K]]
[[Category: Basore, K]]
[[Category: Fremont DH]]
[[Category: Structural genomic]]
[[Category: Kim AS]]
[[Category: Fremont, D H]]
[[Category: Nelson CA]]
[[Category: Kim, A S]]
[[Category: Nelson, C A]]
[[Category: Chikungunya]]
[[Category: Csgid]]
[[Category: Mxra8]]
[[Category: Viral receptor]]
[[Category: Virus]]

Latest revision as of 12:54, 6 November 2024

Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor

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