5qrl: Difference between revisions
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New page: '''Unreleased structure''' The entry 5qrl is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ... |
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The entry | ==PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z437516460== | ||
<StructureSection load='5qrl' size='340' side='right'caption='[[5qrl]], [[Resolution|resolution]] 1.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QRL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NWY:N-[(6-methylpyridin-3-yl)methyl]cyclobutanecarboxamide'>NWY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrl OCA], [https://pdbe.org/5qrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qrl RCSB], [https://www.ebi.ac.uk/pdbsum/5qrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrl ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293] | |||
==See Also== | |||
*[[Brachyury|Brachyury]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Burgess-Brown NA]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: Gavard | [[Category: Fernandez-Cid A]] | ||
[[Category: | [[Category: Gavard AE]] | ||
[[Category: | [[Category: Gileadi O]] | ||
[[Category: Newman JA]] | |||
[[Category: Sherestha L]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:25, 21 February 2024
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z437516460
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