6k3y: Difference between revisions

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'''Unreleased structure'''


The entry 6k3y is ON HOLD  until Paper Publication
==G-quadruplex complex with cyclic dinucleotide 3'-3' cGAMP==
<StructureSection load='6k3y' size='340' side='right'caption='[[6k3y]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K3Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BW:2-AMINO-9-[(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-9-(6-AMINO-9H-PURIN-9-YL)-3,5,10,12-TETRAHYDROXY-5,12-DIOXIDOOCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECIN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE'>4BW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3y OCA], [https://pdbe.org/6k3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k3y RCSB], [https://www.ebi.ac.uk/pdbsum/6k3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3y ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit G-quadruplex structure formation by a sequence containing (4n - 1) guanines, n denoting the number of G-tetrad layers, was previously reported. Here, a (4n - 1) G-quadruplex structure is shown to be capable of binding guanine-containing dinucleotides in micromolar affinity. The guanine base of the dinucleotides interacts with a vacant G-triad, forming four additional Hoogsteen hydrogen bonds to complete a G-tetrad. Solution structures of two complexes, both comprised of a (4n - 1) G-quadruplex structure, one bound to a linear dinucleotide (d(AG)) and the other to a cyclic dinucleotide (cGAMP), are solved using NMR spectroscopy. The latter suggests sufficiently strong interaction between the guanine base of the dinucleotide and the vacant G-triad, which acts as an anchor point of binding. The binding interfaces from the two solution structures provide useful information for specific ligand design. The results also infer that other guanine-containing metabolites of a similar size have the capability of binding G-quadruplexes, potentially affecting the expression of the metabolites and functionality of the bound G-quadruplexes.


Authors: Winnerdy, F.R., Heddi, B., Phan, A.T.
Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides.,Winnerdy FR, Das P, Heddi B, Phan AT J Am Chem Soc. 2019 Nov 13;141(45):18038-18047. doi: 10.1021/jacs.9b05642. Epub , 2019 Oct 29. PMID:31661272<ref>PMID:31661272</ref>


Description: G-quadruplex complex with cyclic dinucleotide 3'-3' cGAMP
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Heddi, B]]
<div class="pdbe-citations 6k3y" style="background-color:#fffaf0;"></div>
[[Category: Phan, A.T]]
== References ==
[[Category: Winnerdy, F.R]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Heddi B]]
[[Category: Phan AT]]
[[Category: Winnerdy FR]]
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