6k50: Difference between revisions

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'''Unreleased structure'''


The entry 6k50 is ON HOLD
==Solution structure of plectasin derivative NZ2114==
 
<StructureSection load='6k50' size='340' side='right'caption='[[6k50]]' scene=''>
Authors: Wang, J.H., Mao, R.Y., Liu, X.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6k50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K50 FirstGlance]. <br>
Description: Solution structure of plectasin derivative NZ2114
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k50 OCA], [https://pdbe.org/6k50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k50 RCSB], [https://www.ebi.ac.uk/pdbsum/6k50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k50 ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Wang, J.H]]
== Function ==
[[Category: Liu, X.H]]
[https://www.uniprot.org/uniprot/DEFPL_PSENR DEFPL_PSENR] Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). It does not disrupt cell membranes (PubMed:20508130). Is especially active against numerous clinical isolates of S.pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292). In vitro, shows considerable selectivity for bacteria over mammalian cells (PubMed:16222292). The peptide synthesized in D-amino acids does not show antibacterial activity (PubMed:19472324). In vitro, acts on voltage-gated potassium channels by moderately inhibiting mammalian Kv1.3/KCNA3 (IC(50)=2.8 uM), and moderately inhibiting others potassium channels (PubMed:25568977).<ref>PMID:16222292</ref> <ref>PMID:25568977</ref>
[[Category: Mao, R.Y]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudoplectania nigrella]]
[[Category: Liu XH]]
[[Category: Mao RY]]
[[Category: Wang JH]]
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