6k5v: Difference between revisions

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'''Unreleased structure'''


The entry 6k5v is ON HOLD
==Structure of CSY4 Apo-form==
<StructureSection load='6k5v' size='340' side='right'caption='[[6k5v]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k5v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K5V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k5v OCA], [https://pdbe.org/6k5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k5v RCSB], [https://www.ebi.ac.uk/pdbsum/6k5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k5v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CISY4_ARATH CISY4_ARATH]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Citrate synthase (CS) catalyzes the conversion of oxaloacetate and acetyl coenzyme A into citrate and coenzyme A in the mitochondrial tricarboxylic acid (TCA) cycle. In plants, mitochondrial metabolism, including the TCA cycle, occurs in interaction with photosynthetic metabolism. The controlled regulation of several enzymes in the TCA cycle, such as CS, is important in plants. Here, the first crystal structure of a plant mitochondrial CS, CSY4 from Arabidopsis thaliana (AtCSY4), has been determined. Structural comparison of AtCSY4 with mitochondrial CSs revealed a high level of similarity. Inhibition analysis showed a similar manner of inhibition as in mitochondrial CSs. The effect of oxidation on one of a pair of cysteine residues in AtCSY4 was speculated upon based on the folded structure.


Authors: Nishio, K., Mizushima, T.
Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana.,Nishio K, Mizushima T Acta Crystallogr F Struct Biol Commun. 2020 Mar 1;76(Pt 3):109-115. doi:, 10.1107/S2053230X20001521. Epub 2020 Mar 1. PMID:32133996<ref>PMID:32133996</ref>


Description: Structure of CSY4 Apo-form
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Mizushima, T]]
<div class="pdbe-citations 6k5v" style="background-color:#fffaf0;"></div>
[[Category: Nishio, K]]
 
==See Also==
*[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Mizushima T]]
[[Category: Nishio K]]
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