6nne: Difference between revisions
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==Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine== | |||
<StructureSection load='6nne' size='340' side='right'caption='[[6nne]], [[Resolution|resolution]] 1.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NNE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.595Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=KUP:5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine'>KUP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nne OCA], [https://pdbe.org/6nne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nne RCSB], [https://www.ebi.ac.uk/pdbsum/6nne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nne ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A5U6B6_MYCTA A5U6B6_MYCTA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194] | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Dias | [[Category: Mycobacterium tuberculosis H37Ra]] | ||
[[Category: | [[Category: Chavez-Pacheco SM]] | ||
[[Category: Dias MVB]] | |||
[[Category: Ribeiro JA]] | |||
Latest revision as of 14:48, 13 March 2024
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine
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