Dual specificity phosphatase: Difference between revisions

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== Function ==
== Function ==


'''Dual specificity phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
'''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>.  There are several DUSP enzymes in mammals sharing a common catalytic mechanism.  The DUSP include:<br />
• '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br />
• '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br />
• '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br />
• '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br />
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</StructureSection>
</StructureSection>
==3D structures of dual specificity phosphatase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Dual specificity phosphatase
**[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human<br />
**[[5xjv]] – hDUSP 13A (mutant) <br />
**[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8<br />
**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
**[[5gtj]]  – hDUSP 26 (mutant) <br />
**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
*Slingshot phosphatase (SSH)
**[[2nt2]]  – hSSH-2L catalytic domain - human<br />
*Phosphatase of regenerating liver (PRL)
**[[1xm2]]  – hPRL-1 (mutant)<br />
**[[1zck]], [[1x24]]  – rPRL-1 - rat<br />
**[[1zcl]] – rPRL-1 (mutant)<br />
**[[1r6h]], [[1v3a]], [[2mbc]]  – hPRL-3 - NMR<br />
*Cdc14
**[[1ohc]], [[1ohd]]  – hCdc14B2 core domain <br />
**[[1ohe]]  – hCdc14B2 core domain + peptide<br />
*Cdc25
**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]]  – hCdc25B catalytic domain <br />
**[[2a2k]], [[2ifd]], [[2ifv]]  – hCdc25B catalytic domain (mutant)<br />
*Phosphoinositide phosphatase PTEN
**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
*Myotubularin-related protein (MTMR)
**[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
**[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
**[[2yf0]] – hMTMR6<br />


*MAPK phosphatase see [[MAP kinase phosphatase]]
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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