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| == Function == | | == Function == |
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| '''Dual specificity phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | | '''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> |
| • '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br /> | | • '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br /> |
| • '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br /> | | • '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br /> |
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| </StructureSection> | | </StructureSection> |
| ==3D structures of dual specificity phosphatase==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Dual specificity phosphatase
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| **[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human<br />
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| **[[5xjv]] – hDUSP 13A (mutant) <br />
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| **[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8<br />
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| **[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
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| **[[5gtj]] – hDUSP 26 (mutant) <br />
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| **[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
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| *Slingshot phosphatase (SSH)
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| **[[2nt2]] – hSSH-2L catalytic domain - human<br />
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| *Phosphatase of regenerating liver (PRL) or protein tyrosine phosphatase type IVA
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| **[[1rxd]] – hPRL-1 <br />
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| **[[1xm2]] – hPRL-1 (mutant)<br />
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| **[[5bx1]] – hPRL-1 + inhibitor<br />
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| **[[1zck]], [[1x24]] – rPRL-1 - rat<br />
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| **[[1zcl]] – rPRL-1 (mutant)<br />
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| **[[3rz2]] – rPRL-1 + peptide<br />
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| **[[5mmz]], [[5lxq]] – mPRL-1 + magnesium transporter - mouse<br />
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| **[[5k24]] – mPRL-2 + magnesium transporter<br />
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| **[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />
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| **[[5k22]] – hPRL-2 (mutant) + magnesium transporter<br />
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| **[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
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| **[[5tsr]] – hPRL-3 + magnesium transporter<br />
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| *Cdc14
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| **[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
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| **[[1ohe]] – hCdc14B2 core domain + peptide<br />
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| **[[6g86]] – hCdc14 + SIC1 peptide<br />
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| **[[6g85]], [[6g84]] – hCdc14 + CBK1 peptide<br />
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| **[[5xw5]] – hCdc14 + SWI6P peptide<br />
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| **[[5xw4]] – yCdc14 - yeast<br />
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| **[[4zj7]] – yCdc14 C-terminal + importin<br />
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| *Cdc25
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| **[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
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| **[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
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| *Phosphoinositide phosphatase PTEN
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| **[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
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| *Phosphoinositide phosphatase Sac1
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| **[[3lwt]] – ySac1<br />
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| **[[4tu3]] – ySac1 + VPS74<br />
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| *Phosphoinositide phosphatase Sac2
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| **[[4xuu]] – hSac2 residues 169-563<br />
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| *Myotubularin-related protein (MTMR)
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| **[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
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| **[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
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| **[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
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| **[[2yf0]] – hMTMR6<br />
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| Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1
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| **[[4rid]], [[4ry3]] – hMTMR15 residues 370-1009<br />
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| **[[4rec]], [[4ri8]], [[4ri9]], [[4ria]], [[4rib]], [[4ric]], [[4reb]], [[4rea]] – hMTMR15 (mutant) + DNA<br />
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| *MAPK phosphatase see [[MAP kinase phosphatase]]
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
