Dynein: Difference between revisions

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'''Dynein''' is a motor protein which walks along the microtubule toward its minus end, i.e. it is a minus-end directed motor.  Dyneins are classified as cytoplasmic (DYNC) or axonemal. The Dyneins are composed of heavy, intermediate and light chains.  For discussion of the DYNC inter mediate and light chains see: [[Dynein light and intermediate chain]].
'''Dynein''' is a motor protein which walks along the microtubule toward its minus end, i.e. it is a minus-end directed motor.  Dyneins are classified as cytoplasmic (DYNC) or axonemal. The '''cytoplasmic dyneins''' are composed of heavy, intermediate and light chains.  They drive processes like cell migration, spindle organisation and chromosome separation in mitosis.  For discussion of the DYNC intermediate and light chains see: [[Dynein light and intermediate chain]].  '''Axonemal dynein''' has only heavy chain and is involved in cilia and flagella movement.


==Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain==
==Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain==
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</StructureSection>
</StructureSection>
== 3D Structures of Dynein ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Dynein light chain
**[[2e8j]], [[2b95]], [[1z09]] - hDYNC 2A – human – NMR<BR />
**[[2hz5]] - hDYNC 2A<BR />
**[[1y4o]] - mDYNC 2A – mouse<BR />
**[[1re6]] - mDYNC 2 – NMR<BR />
**[[5wi4]] - yDYNC TcTex1 - yeast<br />
**[[1pwj]], [[1pwk]], [[1f3c]] - rDYNC 2 – rat – NMR<BR />
**[[5wof]] – DYNC 1 – ''Plasmodium falciparum''<BR />
**[[1xdx]], [[1m9l]], [[1ds9]] - CrDYNC TcTex1 – ''Chlamydomonas reinhardtii'' – NMR<BR />
**[[5yxm]] - CrDYNC <br />
**[[3rjs]] - DYNC – ''Toxoplasma gondii''<br />
**[[5hxl]] – rbfDYNC – rice blast fungus<br />
**[[3dvt]], [[3bri]] - DmDYNC - ''Drosophila melanogaster'' <BR />
**[[3dvh]] - DmDYNC (mutant) <BR />
**[[1rhw]] - DmDYNC - NMR<BR />
**[[1ygt]] - DmDYNC TcTex1<BR />
*Dynein light chain complex
**[[6gzl]], [[6gzj]] - hDYNC 1 + peptide<br />
**[[2xqq]] - hDYNC 2 + peptide<br />
**[[3p8m]] - hDYNC 2 + GCN4<br />
**[[3zke]], [[3zkf]] - hDYNC 1 + NEK9 peptide<br />
**[[4d07]] - hDYNC 2 + myosin peptide<br />
**[[3tq7]] – hDYNC 1 + EB1C/EB3C<br />
**[[1f95]], [[1f96]] - rDYNC + peptide – NMR<BR />
**[[4ds1]] - yDYNC + nucleoporin Nup129 peptide <br />
**[[4ht6]] – yDYNC + PAC11 peptide<br />
**[[4qh8]], [[4qh7]] - DmDYNC + anastral spindle 2<br />
**[[3dvp]], [[3brl]], [[3e2b]], [[5e0l]], [[5e0m]] - DmDYNC + peptide<BR />
*Dynein intermediate chain
**[[3l7h]] – DmDYNC intermediate chain light chain roadblock <BR />
**[[3l9k]] - DmDYNC intermediate chain light chain roadblock + intermediate chain<BR />
**[[3fm7]], [[3glw]], [[2pg1]], [[2p2t]] - DmDYNC intermediate chain + light chain<br />
**[[5hyc]] – rbfDYNC 2<br />
*Dynein light+intermediate chains
**[[5jpw]] – hDYNC - NMR<br />
**[[6f1z]] – hDYNC – Cryo EM<br />
**[[6b9h]] - hDYNC + protein hook homolog<br />
**[[4w7g]] – DYNC – ''Chaetomium thermophilum''<br />
*Dynein heavy chain
**[[5owo]] – hDYNC <br />
**[[5ayh]] – mDYNC <br />
**[[3err]] - mDYNC microtubule-binding domain/Ser-tRNA synthetase<br />
**[[3wuq]] - mDYNC stalk domain<br />
**[[3j1t]] - mDYNC + tubulin α-1B chain<br />
**[[3j1u]] - mDYNC + tubulin α-1B+β-2B chains<br />
**[[5afr]] – yDYNC N terminal<br />
**[[3qmz]] – yDYNC + glutathione-S-transferase <BR />
**[[4w8f]] – yDYNC/lysozyme (mutant) + AMPPNP<br />
**[[5vh9]], [[5vlj]] – yDYNC + LIS1 + ATP - CryoEM<br />
**[[3vkg]], [[3vkh]] - DYNC – ''Dictyostelium discoideum''<br />
**[[2rr7]] – CrDYNC microtubule-binding domain<br />
**[[3j6p]] - DYNC + tubulin α-1B chain – slime mold<br />
*Dynein motor domain
**[[4rh7]] – hDYNC + ADP + ATP<br />
**[[4aki]], [[4akg]] – yDYNC + ATP<br />
**[[4akh]] – yDYNC + AMPPNP<br />
**[[4ai6]] – yDYNC + ADP<br />
**[[3j68]], [[3j67]] – DYNC – sea urchin<br />
*Dynein tail
**[[6f1y]] – hDCTN heavy+light+intermediate – CryoEM<br />
**[[5nvs]] – hDCTN heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
**[[5nvu]] – hDCTN motor+heavy+light+intermediate + LC8 + TcTex + ROBL – CryoEM<br />
**[[5nw4]] – hDCTN heavy+light+intermediate + APR1 + APR11 + ROBL + beta-actin + capping protein + dynactin + P150 + BICD2N – CryoEM<br />
**[[5afu]] – pDCTN subunits 2,3,5,6 + dynein tail + capping protein - pig – CryoEM<br />
**[[6f3a]] – pDYNC heavy+light+intermediate + dynactin + BICD2N  - Cryo EM<br />
**[[6f1u]], [[6f1t]] – pDYNC heavy+light+intermediate + dynactin + BICDR1  - Cryo EM<br />
**[[6f38]] – pDYNC heavy+light+intermediate + dynactin + HOOK3 - Cryo EM<br />
}}


==References==
==References==
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