Exoenzyme: Difference between revisions

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<StructureSection load='2c8c' size='400' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene='59/593306/Cv/8'>
<StructureSection load='2c8c' size='400' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene='59/593306/Cv/8'>


'''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells.  The breakdown components can pass through the cell wall.  '''Exo C3''' is a ''Clostridium butulinum'' toxin which binds [[NAD]], splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity<ref>PMID:11114250</ref> .
'''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells.  The breakdown components can pass through the cell wall.   
*'''Exo C3''' is a ''Clostridium butulinum'' toxin which binds [[NAD]], splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate.  
* '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity<ref>PMID:11114250</ref> .


<scene name='59/593306/Cv/6'>NAD binding site</scene>.
<scene name='59/593306/Cv/6'>NAD binding site</scene>.
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</StructureSection>
</StructureSection>
==3D structures of exoenzyme==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Exoenzyme C3
**[[1g24]] – CbExo residues 8-218 – ''Clostridium butulinum''<br />
**[[1uzi]], [[1r45]], [[1r4b]], [[2c89]] – CbExo catalytic domain <br />
**[[1gze]], [[2c8b]], [[2c8d]], [[2c8e]], [[2c8g]] – CbExo catalytic domain (mutant)<br />
**[[3bw8]] - Exo catalytic domain - ''Clostridium limosum''<br />
*Exoenzyme C3 complexes
**[[1gzf]] – CbExo catalytic domain + pyridinium derivative + ADP + NAD<br />
**[[2bov]] – CbExo + GDP + Ral-A GTPase<br />
**[[2a78]] – CbExo catalytic domain + GDP + Ral-A GTPase<br />
**[[2a9k]] – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD<br />
**[[2c8a]] – CbExo catalytic domain + nicotinamide<br />
**[[2c8c]] – CbExo catalytic domain (mutant) + ADP + NAD<br />
**[[2c8f]], [[2c8h]] – CbExo catalytic domain (mutant) + NAD<br />
*Exoenzyme S
**[[1r4t]] – PaExo S GAP domain – ''Pseudomonas aeruginosa'' - NMR<br />
**[[1he1]] – PaExo S GAP domain + Ras-like protein + GDP <br />
**[[1he9]] – PaExo S GAP domain + Ras-like protein <br />
**[[6gn0]], [[6gn8]], [[6gnj]] – PaExo S residues 235-457 (mutant) + 14-3-3 protein β/α<br />
**[[6gnk]] – PaExo S residues 235-457 (mutant) + 14-3-3 protein β/α + NAD derivative<br />
**[[4zua]] – PaExo SA regulatory domain residues 2-178 <br />
**[[3kxy]] – PaExo SC residues 1-133 + PaExo SE residues 16-81<br />
*Exoenzyme T
**[[4jmf]] – PaExo residues 28-77 + chaperone<br />
**[[6jnp]] – PaExo residues 23-79 + YOPE rgulator<br />
**[[6gnn]] – PaExo residues 235-457 + 14-3-3 protein β/α<br />
}}


== References ==
== References ==
Retrieved from "https://proteopedia.org/Exoenzyme"