2qze: Difference between revisions

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[[Image:2qze.jpg|left|200px]]


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==Monoclinic Mimivirus Capping Enzyme Triphosphatase.==
The line below this paragraph, containing "STRUCTURE_2qze", creates the "Structure Box" on the page.
<StructureSection load='2qze' size='340' side='right'caption='[[2qze]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qze OCA], [https://pdbe.org/2qze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qze RCSB], [https://www.ebi.ac.uk/pdbsum/2qze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qze ProSAT]</span></td></tr>
{{STRUCTURE_2qze|  PDB=2qze  |  SCENE= }}
</table>
 
== Function ==
'''Monoclinic Mimivirus Capping Enzyme Triphosphatase.'''
[https://www.uniprot.org/uniprot/MCE_MIMIV MCE_MIMIV] Responsible for methylating the 5'-cap structure of mRNAs.
 
<div style="background-color:#fffaf0;">
 
== Publication Abstract from PubMed ==
==Overview==
The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to the cysteinyl-phosphatase RTPases of their metazoan host organisms. The origins of DNA virus RTPases are unclear because they are structurally uncharacterized. Mimivirus, a giant virus of amoeba, resembles poxviruses in having a trifunctional capping enzyme composed of a metal-dependent RTPase module fused to guanylyltransferase (GTase) and guanine-N7 methyltransferase domains. The crystal structure of mimivirus RTPase reveals a minimized tunnel fold and an active site strikingly similar to that of Cet1. Unlike homodimeric fungal RTPases, mimivirus RTPase is a monomer. The mimivirus TTM-type RTPase-GTase fusion resembles the capping enzymes of amoebae, providing evidence that the ancestral large DNA virus acquired its capping enzyme from a unicellular host.
The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to the cysteinyl-phosphatase RTPases of their metazoan host organisms. The origins of DNA virus RTPases are unclear because they are structurally uncharacterized. Mimivirus, a giant virus of amoeba, resembles poxviruses in having a trifunctional capping enzyme composed of a metal-dependent RTPase module fused to guanylyltransferase (GTase) and guanine-N7 methyltransferase domains. The crystal structure of mimivirus RTPase reveals a minimized tunnel fold and an active site strikingly similar to that of Cet1. Unlike homodimeric fungal RTPases, mimivirus RTPase is a monomer. The mimivirus TTM-type RTPase-GTase fusion resembles the capping enzymes of amoebae, providing evidence that the ancestral large DNA virus acquired its capping enzyme from a unicellular host.


==About this Structure==
Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain.,Benarroch D, Smith P, Shuman S Structure. 2008 Apr;16(4):501-12. PMID:18400173<ref>PMID:18400173</ref>
2QZE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZE OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain., Benarroch D, Smith P, Shuman S, Structure. 2008 Apr;16(4):501-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18400173 18400173]
</div>
[[Category: Mimivirus]]
<div class="pdbe-citations 2qze" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Benarroch, D.]]
<references/>
[[Category: Shuman, S.]]
__TOC__
[[Category: Smith, P.]]
</StructureSection>
[[Category: Capping]]
[[Category: Large Structures]]
[[Category: Hydrolase]]
[[Category: Mimivirus]]
[[Category: Mimivirus]]
[[Category: Monoclinic]]
[[Category: Benarroch D]]
[[Category: Mrna capping]]
[[Category: Shuman S]]
[[Category: Mrna processing]]
[[Category: Smith P]]
[[Category: Multifunctional enzyme]]
[[Category: Nucleotidyltransferase]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Transferase]]
[[Category: Triphosphatase]]
[[Category: Tunnel]]
[[Category: Viral protein]]
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Retrieved from "https://proteopedia.org/2qze"