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<StructureSection load='5ajn' size='340' side='right'caption='[[5ajn]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='5ajn' size='340' side='right'caption='[[5ajn]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ajn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ajn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajo|5ajo]], [[5ajp|5ajp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajn OCA], [https://pdbe.org/5ajn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ajn RCSB], [https://www.ebi.ac.uk/pdbsum/5ajn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajn OCA], [http://pdbe.org/5ajn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ajn RCSB], [http://www.ebi.ac.uk/pdbsum/5ajn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
[https://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
[[Category: Bernado P]]
[[Category: Bernado, P]]
[[Category: Bernardes GJL]]
[[Category: Bernardes, G J.L]]
[[Category: Bruscolini P]]
[[Category: Bruscolini, P]]
[[Category: Clausen H]]
[[Category: Clausen, H]]
[[Category: Companon I]]
[[Category: Companon, I]]
[[Category: Corzana F]]
[[Category: Corzana, F]]
[[Category: Hurtado-Guerrero R]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Iglesias-Fernandez J]]
[[Category: Iglesias-Fernandez, J]]
[[Category: Kong Y]]
[[Category: Kong, Y]]
[[Category: Lira-Navarrete E]]
[[Category: Lira-Navarrete, E]]
[[Category: Lostao A]]
[[Category: Lostao, A]]
[[Category: Pallares MC]]
[[Category: Pallares, M C]]
[[Category: Peregrina JM]]
[[Category: Peregrina, J M]]
[[Category: Rovira C]]
[[Category: Rovira, C]]
[[Category: DelasRivas M]]
[[Category: DelasRivas, M]]
[[Category: Active form]]
[[Category: Afm]]
[[Category: Coarse-grained model]]
[[Category: Compact form]]
[[Category: Extended form]]
[[Category: Glycopeptide]]
[[Category: Inactive form]]
[[Category: Lectin domain]]
[[Category: Sax]]
[[Category: Transferase]]
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