6ijl: Difference between revisions

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'''Unreleased structure'''


The entry 6ijl is ON HOLD
==Crystal structure of SmyD3 in complex with covalent inhibitor 5==
<StructureSection load='6ijl' size='340' side='right'caption='[[6ijl]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ijl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IJL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.351&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8U:propyl+(2~{R})-4-[2-[4-(1-azanylcyclopropyl)phenyl]quinolin-7-yl]carbonyl-2-methyl-piperazine-1-carboxylate'>A8U</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ijl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ijl OCA], [https://pdbe.org/6ijl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ijl RCSB], [https://www.ebi.ac.uk/pdbsum/6ijl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ijl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>


Authors: Baburajendran, N., Joy, J.
==See Also==
 
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
Description: Crystal structure of SmyD3 in complex with covalent inhibitor 5
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Joy, J]]
__TOC__
[[Category: Baburajendran, N]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baburajendran N]]
[[Category: Joy J]]
Retrieved from "https://proteopedia.org/6ijl"