6pk6: Difference between revisions

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'''Unreleased structure'''


The entry 6pk6 is ON HOLD
==Human PRPF4B bound to benzothiophene inhibitor 329==
 
<StructureSection load='6pk6' size='340' side='right'caption='[[6pk6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Godoi, P.H.C., Santiago, A.S., Fala, A.M., Ramos, P.Z., Sriranganadane, D., Mascarello, A., Segretti, N., Azevedo, H., Guimaraes, C.R.W., Arruda, P., Elkins, J.M., Counago, R.M., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6pk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PK6 FirstGlance]. <br>
Description: Human PRPF4B bound to benzothiophene inhibitor 329
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OND:4-[5-[(2-aminophenyl)methylcarbamoyl]thiophen-2-yl]-1-benzothiophene-2-carboxamide'>OND</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Fala, A.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk6 OCA], [https://pdbe.org/6pk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pk6 RCSB], [https://www.ebi.ac.uk/pdbsum/6pk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk6 ProSAT]</span></td></tr>
[[Category: Elkins, J.M]]
</table>
[[Category: Guimaraes, C.R.W]]
== Function ==
[[Category: Segretti, N]]
[https://www.uniprot.org/uniprot/PRP4K_HUMAN PRP4K_HUMAN] Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716).<ref>PMID:10799319</ref> <ref>PMID:11418604</ref> <ref>PMID:12077342</ref> <ref>PMID:17513757</ref> <ref>PMID:17998396</ref> <ref>PMID:20118938</ref> <ref>PMID:29695716</ref>
[[Category: Arruda, P]]
== References ==
[[Category: Structural Genomics Consortium (Sgc)]]
<references/>
[[Category: Santiago, A.S]]
__TOC__
[[Category: Sriranganadane, D]]
</StructureSection>
[[Category: Azevedo, H]]
[[Category: Homo sapiens]]
[[Category: Mascarello, A]]
[[Category: Large Structures]]
[[Category: Counago, R.M]]
[[Category: Arruda P]]
[[Category: Ramos, P.Z]]
[[Category: Azevedo H]]
[[Category: Godoi, P.H.C]]
[[Category: Counago RM]]
[[Category: Elkins JM]]
[[Category: Fala AM]]
[[Category: Godoi PHC]]
[[Category: Guimaraes CRW]]
[[Category: Mascarello A]]
[[Category: Ramos PZ]]
[[Category: Santiago AS]]
[[Category: Segretti N]]
[[Category: Sriranganadane D]]
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