6s8k: Difference between revisions
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==Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes== | |||
<StructureSection load='6s8k' size='340' side='right'caption='[[6s8k]], [[Resolution|resolution]] 1.52Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s8k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PN6:(3Z,6Z)-3-BENZYLIDENE-6-[(5-TERT-BUTYL-1H-IMIDAZOL-4-YL)METHYLIDENE]PIPERAZINE-2,5-DIONE'>PN6</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8k OCA], [http://pdbe.org/6s8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8k RCSB], [http://www.ebi.ac.uk/pdbsum/6s8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8k ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Olieric, N]] | |||
[[Category: Sharma, A]] | |||
[[Category: Steinmetz, M]] | |||
[[Category: Cancer]] | |||
[[Category: Microtubule]] | |||
[[Category: Microtubule targeting agent]] | |||
[[Category: Structural protein]] | |||
[[Category: Tubulin]] | |||
