3k6p: Difference between revisions

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<StructureSection load='3k6p' size='340' side='right'caption='[[3k6p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3k6p' size='340' side='right'caption='[[3k6p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3k6p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6P FirstGlance]. <br>
<table><tr><td colspan='2'>[[3k6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FB:4-(4-{[(5R)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YL]METHYL}-2-METHOXYPHENOXY)-3-(TRIFLUOROMETHYL)BENZONITRILE'>5FB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.996&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERR1, ESRL1, ESRRA, NR3B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FB:4-(4-{[(5R)-2,4-DIOXO-1,3-THIAZOLIDIN-5-YL]METHYL}-2-METHOXYPHENOXY)-3-(TRIFLUOROMETHYL)BENZONITRILE'>5FB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6p OCA], [http://pdbe.org/3k6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6p RCSB], [http://www.ebi.ac.uk/pdbsum/3k6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6p OCA], [https://pdbe.org/3k6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6p RCSB], [https://www.ebi.ac.uk/pdbsum/3k6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ERR1_HUMAN ERR1_HUMAN]] Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.<ref>PMID:9271417</ref> <ref>PMID:12522104</ref> <ref>PMID:16150865</ref> <ref>PMID:17676930</ref> <ref>PMID:18063693</ref>
[https://www.uniprot.org/uniprot/ERR1_HUMAN ERR1_HUMAN] Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.<ref>PMID:9271417</ref> <ref>PMID:12522104</ref> <ref>PMID:16150865</ref> <ref>PMID:17676930</ref> <ref>PMID:18063693</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abad, M C]]
[[Category: Abad MC]]
[[Category: Patch, R J]]
[[Category: Patch RJ]]
[[Category: Dna-binding]]
[[Category: Estrogen related receptor alpha]]
[[Category: Hormone receptor]]
[[Category: Isopeptide bond]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Receptor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]

Latest revision as of 08:10, 6 September 2023

Estrogen Related Receptor alpha in Complex with an Ether Based Ligand

3k6p, resolution 2.00Å

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