GTP-binding protein: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='46/463251/Cv/ | <StructureSection load='' size='350' side='right' scene='46/463251/Cv/10' caption='E. coli small GTP-binding protein ERA complex with GDP and sulfate (PDB code [[3ieu]])'> | ||
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> see [[Transducin]] and '''small GTPases'''<ref>PMID:11152757</ref>. | '''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> see [[Transducin]] and '''small GTPases'''<ref>PMID:11152757</ref>. | ||
*'''Small GTPase''' structure is homologous to that of the α subunit of heterotrimeric G protein. See details on '''small GTP-binding protein LepA''' in [[LepA]]. | |||
*'''Nucleolar GTP-binding proteins''' are involved in the biogenesis of ribosome<ref>PMID:24552710</ref>. | |||
'''Heterotrimeric G protein or guanine nucleotide-binding protein or G protein''' (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. | *'''Heterotrimeric G protein or guanine nucleotide-binding protein or G protein''' (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. See also<br /> | ||
[[G protein-coupled receptor]]<br /> | [[G protein-coupled receptor]]<br /> | ||
[[Beta2 adrenergic receptor-Gs protein complex]] | [[Beta2 adrenergic receptor-Gs protein complex updated]]<br /> | ||
[[Dedicator of cytokinesis protein]] | |||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/ | ''E. coli'' <scene name='46/463251/Cv/11'>small GTPase ERA binds GDP in a cavity</scene> formed by <scene name='46/463251/Cv/9'>7 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/8'>GDP binding site</scene>. Water molecules are shown as red spheres. | ||
== 3D Structures of GTP-binding protein == | == 3D Structures of GTP-binding protein == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] [[Category:G protein]] | ||
