6khe: Difference between revisions

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New page: '''Unreleased structure''' The entry 6khe is ON HOLD Authors: Lee, J.Y., Yun, J.S., Jin, H., Chang, J.H. Description: Crystal structure of CLK2 in complex with CX-4945 [[Category: Unre...
 
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'''Unreleased structure'''


The entry 6khe is ON HOLD
==Crystal structure of CLK2 in complex with CX-4945==
<StructureSection load='6khe' size='340' side='right'caption='[[6khe]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6khe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KHE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NG:5-[(3-CHLOROPHENYL)AMINO]BENZO[C][2,6]NAPHTHYRIDINE-8-CARBOXYLIC+ACID'>3NG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6khe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6khe OCA], [https://pdbe.org/6khe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6khe RCSB], [https://www.ebi.ac.uk/pdbsum/6khe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6khe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLK2_HUMAN CLK2_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> <ref>PMID:8910305</ref> <ref>PMID:9637771</ref>


Authors: Lee, J.Y., Yun, J.S., Jin, H., Chang, J.H.
==See Also==
 
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
Description: Crystal structure of CLK2 in complex with CX-4945
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Jin, H]]
__TOC__
[[Category: Yun, J.S]]
</StructureSection>
[[Category: Lee, J.Y]]
[[Category: Homo sapiens]]
[[Category: Chang, J.H]]
[[Category: Large Structures]]
[[Category: Chang JH]]
[[Category: Jin H]]
[[Category: Lee JY]]
[[Category: Yun JS]]
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