2ywk: Difference between revisions
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==Crystal structure of RRM-domain derived from human putative RNA-binding protein 11== | |||
<StructureSection load='2ywk' size='340' side='right'caption='[[2ywk]], [[Resolution|resolution]] 1.54Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ywk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YWK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ywk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ywk OCA], [https://pdbe.org/2ywk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ywk RCSB], [https://www.ebi.ac.uk/pdbsum/2ywk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ywk ProSAT], [https://www.topsan.org/Proteins/RSGI/2ywk TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RBM11_HUMAN RBM11_HUMAN] Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.<ref>PMID:21984414</ref> | |||
== Evolutionary Conservation == | |||
== | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2ywk_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ywk ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Kaminishi | [[Category: Kaminishi T]] | ||
[[Category: Kawazoe | [[Category: Kawazoe M]] | ||
[[Category: Morita | [[Category: Morita S]] | ||
[[Category: Nishino | [[Category: Nishino A]] | ||
[[Category: Shirouzu M]] | |||
[[Category: Shirouzu | [[Category: Takemoto C]] | ||
[[Category: Takemoto | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Uchikubo-Kamo T]] | ||
[[Category: Uchikubo-Kamo | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 08:40, 30 October 2024
Crystal structure of RRM-domain derived from human putative RNA-binding protein 11
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