6k6n: Difference between revisions

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'''Unreleased structure'''


The entry 6k6n is ON HOLD  until Paper Publication
==Crystal structure of SIVmac239 Nef protein==
<StructureSection load='6k6n' size='340' side='right'caption='[[6k6n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0002&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6n OCA], [https://pdbe.org/6k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6n RCSB], [https://www.ebi.ac.uk/pdbsum/6k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q203Y4_SIV Q203Y4_SIV]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The human immunodeficiency virus (HIV) accessory protein Nef plays a major role in establishing and maintaining infection, particularly through immune evasion. Many HIV-2-infected people experience long-term viral control and survival, resembling HIV-1 elite control. HIV-2 Nef has overlapping but also distinct functions from HIV-1 Nef. Here we report the crystal structure of HIV-2 Nef core. The di-leucine sorting motif forms a helix bound to neighboring molecules, and moreover, isothermal titration calorimetry demonstrated that the CD3 endocytosis motif can directly bind to HIV-2 Nef, ensuring AP-2-mediated endocytosis for CD3. The highly conserved C-terminal region forms a alpha-helix, absent from HIV-1. We further determined the structure of simian immunodeficiency virus (SIV) Nef harboring this region, demonstrating similar C-terminal alpha-helix, which may contribute to AP-1 binding for MHC-I downregulation. These results provide insights into the distinct pathogenesis of HIV-2 infection.


Authors:  
Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation.,Hirao K, Andrews S, Kuroki K, Kusaka H, Tadokoro T, Kita S, Ose T, Rowland-Jones SL, Maenaka K iScience. 2020 Jan 24;23(1):100758. doi: 10.1016/j.isci.2019.100758. Epub 2019, Dec 9. PMID:31927483<ref>PMID:31927483</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6k6n" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Protein Nef 3D structures|Protein Nef 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Simian immunodeficiency virus]]
[[Category: Andrews S]]
[[Category: Hirao K]]
[[Category: Kita S]]
[[Category: Kuroki K]]
[[Category: Kusaka H]]
[[Category: Maenaka K]]
[[Category: Ose T]]
[[Category: Rowland-Jones S]]
[[Category: Tadokoro T]]
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