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New page: '''Unreleased structure''' The entry 6kiv is ON HOLD Authors: Huang, J., Xue, H., Yao, T. Description: Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) [[Category: Unreleas...
 
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'''Unreleased structure'''


The entry 6kiv is ON HOLD
==Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom)==
<SX load='6kiv' size='340' side='right' viewer='molstar' caption='[[6kiv]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6kiv]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KIV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kiv OCA], [https://pdbe.org/6kiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kiv RCSB], [https://www.ebi.ac.uk/pdbsum/6kiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kiv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


Authors: Huang, J., Xue, H., Yao, T.
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
Description: Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom)
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
[[Category: Unreleased Structures]]
*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
[[Category: Xue, H]]
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
[[Category: Huang, J]]
__TOC__
[[Category: Yao, T]]
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Huang J]]
[[Category: Xue H]]
[[Category: Yao T]]
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