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<StructureSection load='6otn' size='340' side='right'caption='[[6otn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6otn' size='340' side='right'caption='[[6otn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6otn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OTN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6otn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6otn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6otn OCA], [http://pdbe.org/6otn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6otn RCSB], [http://www.ebi.ac.uk/pdbsum/6otn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6otn ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6otn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6otn OCA], [https://pdbe.org/6otn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6otn RCSB], [https://www.ebi.ac.uk/pdbsum/6otn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6otn ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TPM3_HUMAN TPM3_HUMAN]] Childhood-onset nemaline myopathy;Cap myopathy;Congenital fiber-type disproportion myopathy;Inflammatory myofibroblastic tumor;Intermediate nemaline myopathy;Congenital generalized hypercontractile muscle stiffness syndrome. The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.<ref>PMID:2869410</ref>  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/TPM3_HUMAN TPM3_HUMAN] Childhood-onset nemaline myopathy;Cap myopathy;Congenital fiber-type disproportion myopathy;Inflammatory myofibroblastic tumor;Intermediate nemaline myopathy;Congenital generalized hypercontractile muscle stiffness syndrome. The disease is caused by mutations affecting the gene represented in this entry.  A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.<ref>PMID:2869410</ref>  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TPM3_HUMAN TPM3_HUMAN]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.[UniProtKB:P09493]  
[https://www.uniprot.org/uniprot/TPM3_HUMAN TPM3_HUMAN] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.[UniProtKB:P09493]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6otn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6otn" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tropomyosin|Tropomyosin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ghosh, A]]
[[Category: Ghosh A]]
[[Category: Gunning, P W]]
[[Category: Gunning PW]]
[[Category: Janco, M]]
[[Category: Janco M]]
[[Category: Lehman, W J]]
[[Category: Lehman WJ]]
[[Category: Rynkiewicz, M J]]
[[Category: Rynkiewicz MJ]]
[[Category: Coiled coil]]
[[Category: Fragment]]
[[Category: Structural protein]]
[[Category: Tropomyosin]]
Retrieved from "https://proteopedia.org/6otn"