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==THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY==
==THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY==
<StructureSection load='1atx' size='340' side='right'caption='[[1atx]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''>
<StructureSection load='1atx' size='340' side='right'caption='[[1atx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1atx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anesu Anesu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ATX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1atx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anemonia_sulcata Anemonia sulcata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ATX FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atx OCA], [http://pdbe.org/1atx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1atx RCSB], [http://www.ebi.ac.uk/pdbsum/1atx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1atx ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 8 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atx OCA], [https://pdbe.org/1atx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1atx RCSB], [https://www.ebi.ac.uk/pdbsum/1atx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1atx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TXA1_ANESU TXA1_ANESU]] Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.  
[https://www.uniprot.org/uniprot/NA11_ANESU NA11_ANESU] Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current.<ref>PMID:2409523</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/1atx_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/1atx_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anesu]]
[[Category: Anemonia sulcata]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Billeter, M]]
[[Category: Billeter M]]
[[Category: Widmer, H]]
[[Category: Widmer H]]
[[Category: Wuthrich, K]]
[[Category: Wuthrich K]]
[[Category: Sea anemone toxin]]
Retrieved from "https://proteopedia.org/1atx"