1a8i: Difference between revisions

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<StructureSection load='1a8i' size='340' side='right'caption='[[1a8i]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='1a8i' size='340' side='right'caption='[[1a8i]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1a8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8I FirstGlance]. <br>
<table><tr><td colspan='2'>[[1a8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8I FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLS:BETA-D-GLUCOPYRANOSE+SPIROHYDANTOIN'>GLS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLS:BETA-D-GLUCOPYRANOSE+SPIROHYDANTOIN'>GLS</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8i OCA], [https://pdbe.org/1a8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8i RCSB], [https://www.ebi.ac.uk/pdbsum/1a8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8i OCA], [http://pdbe.org/1a8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a8i RCSB], [http://www.ebi.ac.uk/pdbsum/1a8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.  
[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: De La Fuente C]]
[[Category: Fleet, G W.J]]
[[Category: Fleet GWJ]]
[[Category: Fuente, C De La]]
[[Category: Garman EF]]
[[Category: Garman, E F]]
[[Category: Gregoriou M]]
[[Category: Gregoriou, M]]
[[Category: Johnson LN]]
[[Category: Johnson, L N]]
[[Category: Krulle TM]]
[[Category: Krulle, T M]]
[[Category: Noble MEM]]
[[Category: Noble, M E.M]]
[[Category: Oikonomakos NG]]
[[Category: Oikonomakos, N G]]
[[Category: Watson KA]]
[[Category: Watson, K A]]
[[Category: Anti-hyperglycemic agent]]
[[Category: Glucopyranose spirohydantoin]]
[[Category: Glycogen phosphorylase]]
[[Category: Inhibitor binding]]
[[Category: Water structure]]
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