Rhomboid protease: Difference between revisions
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<StructureSection load='' size='450' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene='55/551211/Cv/1'> | <StructureSection load='' size='450' side='right' caption='Structure of rhomboid protease complex with inhibitor isocoumarin and nonyglucoside detergent molecules (PDB entry [[2xow]])' scene='55/551211/Cv/1'> | ||
== Function == | == Function == | ||
'''Rhomboid protease''' (GlpG) is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | '''Rhomboid protease''' ('''GlpG''') is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | ||
*'''Rhomboid protease YqgP''' interacts with the membrane bound metlloprotease FisH and cleaves the high-affinity Mg transporter<ref>PMID:31930742</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Rhomboid protease | *Rhomboid protease GlpG | ||
**[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | **[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR /> | ||
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**[[2gqc]] – RP N terminal – NMR – ''Pseudomonas aeruginosa''<br /> | **[[2gqc]] – RP N terminal – NMR – ''Pseudomonas aeruginosa''<br /> | ||
*Rhomboid protease complex with inhibitor | *Rhomboid protease GlpG complex with inhibitor | ||
**[[2xow]], [[3zeb]] – EcGlpG core region + isocoumarin inhibitor <BR /> | **[[2xow]], [[3zeb]] – EcGlpG core region + isocoumarin inhibitor <BR /> | ||
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**[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | **[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR /> | ||
**[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | **[[3zmh]], [[3zmi]], [[3zmj]], [[3zot]] – EcGlpG core region + β-lactam inhibitor <BR /> | ||
**[[5f5j]], [[5f5k]] – EcGlpG core region (mutant) + aldehyde inhibitor <BR /> | **[[6pj5]], [[6pj7]], [[6pj8]], [[6pj9]], [[6pja]], [[6pjp]], [[6pjq]], [[6pjr]], [[6pju]] – EcGlpG core region + peptide aldehyde inhibitor <BR /> | ||
**[[4qo0]], [[4qo2]], [[5f5g]], [[5f5b]], [[5mtf]], [[5mt6]], [[5mt7]], [[5mt8]] – EcGlpG core region + peptide inhibitor <BR /> | **[[5f5j]], [[5f5k]], [[6pj4]] – EcGlpG core region (mutant) + peptide aldehyde inhibitor <BR /> | ||
**[[4qo0]], [[4qo2]], [[5f5g]], [[5f5b]], [[5mtf]], [[5mt6]], [[5mt7]], [[5mt8]], [[6vj8]], [[6jv9]], [[6vjp]], [[6xro]], [[6xrp]] – EcGlpG core region + peptide inhibitor <BR /> | |||
**[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | **[[4qnz]] – EcGlpG core region (mutant) + peptide inhibitor <BR /> | ||
*Rhomboid protease YqgP | |||
**[[6r0j]] – YqpG – ''Bacillus subtilis'' - NMR <BR /> | |||
*Rhomboid protease GluP | |||
**[[7tj4]] – GluP + LytH – ''Staphylococcus aureus'' <BR /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
