6sm7: Difference between revisions
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==Crystal structure of SLA Reductase YihU from E. Coli== | |||
<StructureSection load='6sm7' size='340' side='right'caption='[[6sm7]], [[Resolution|resolution]] 1.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6sm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SM7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene></td></tr> | ||
[[Category: Davies | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm7 OCA], [https://pdbe.org/6sm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sm7 RCSB], [https://www.ebi.ac.uk/pdbsum/6sm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm7 ProSAT]</span></td></tr> | ||
[[Category: Sharma | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SQUU_ECOLI SQUU_ECOLI] Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS) (PubMed:24463506, Ref.6). Metabolite profiling studies showed that the enzyme also catalyzes in vitro the NADH-dependent reduction of succinic semialdehyde (SSA) to 4-hydroxybutyrate (GHB), and that it could be involved in the metabolism of SSA, and other potentially toxic intermediates that may accumulate under stress conditions (PubMed:19372223). However, the enzyme exhibits a 42,000-fold greater catalytic efficiency for the reduction of SLA over SSA (Ref.6). Shows no detectable activity on the analogous glycolytic intermediate glyceraldehyde-3-phosphate (Ref.6).<ref>PMID:19372223</ref> <ref>PMID:24463506</ref> <ref>PMID:24463506</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Large Structures]] | |||
[[Category: Davies GJ]] | |||
[[Category: Sharma M]] | |||
Latest revision as of 12:44, 24 January 2024
Crystal structure of SLA Reductase YihU from E. Coli
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