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==Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)==
==Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)==
<StructureSection load='6pkw' size='340' side='right'caption='[[6pkw]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
<SX load='6pkw' size='340' side='right' viewer='molstar' caption='[[6pkw]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6pkw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PKW FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pkw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PKW FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pkw OCA], [http://pdbe.org/6pkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pkw RCSB], [http://www.ebi.ac.uk/pdbsum/6pkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pkw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pkw OCA], [https://pdbe.org/6pkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pkw RCSB], [https://www.ebi.ac.uk/pdbsum/6pkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pkw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPM2_DANRE TRPM2_DANRE] Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.<ref>PMID:30250252</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Borgnia, M J]]
[[Category: Borgnia MJ]]
[[Category: Borschel, W F]]
[[Category: Borschel WF]]
[[Category: Hsu, A L]]
[[Category: Hsu AL]]
[[Category: Lander, G C]]
[[Category: Lander GC]]
[[Category: Lee, S Y]]
[[Category: Lee S-Y]]
[[Category: Wu, M]]
[[Category: Wu M]]
[[Category: Yin, Y]]
[[Category: Yin Y]]
[[Category: Adp-ribose]]
[[Category: Calcium-permeable ion channel]]
[[Category: Ion channel]]
[[Category: Redox sensor]]
[[Category: Transport protein]]
[[Category: Trp channel]]
[[Category: Trpm channel]]
[[Category: Warmth sensor]]
Retrieved from "https://proteopedia.org/6pkw"