5xna: Difference between revisions

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<StructureSection load='5xna' size='340' side='right'caption='[[5xna]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5xna' size='340' side='right'caption='[[5xna]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xna]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ramva Ramva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XNA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ramazzottius_varieornatus Ramazzottius varieornatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XNA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SHV:HEPTANOIC+ACID'>SHV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.802&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SAHS1, RvY_02423-1, RvY_02423.1, RvY_02423 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=947166 RAMVA])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SHV:HEPTANOIC+ACID'>SHV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xna OCA], [http://pdbe.org/5xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xna RCSB], [http://www.ebi.ac.uk/pdbsum/5xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xna ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xna OCA], [https://pdbe.org/5xna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xna RCSB], [https://www.ebi.ac.uk/pdbsum/5xna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xna ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SAHS1_RAMVA SAHS1_RAMVA]] Secreted heat soluble protein acting as a molecular shield in water-deficient condition (PubMed:22937162). Tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance by forming non-crystalline amorphous solids upon desiccation, and this vitrified state mirrors their protective capabilities (By similarity).[UniProtKB:P0CU39]<ref>PMID:22937162</ref> 
[https://www.uniprot.org/uniprot/SAHS1_RAMVA SAHS1_RAMVA] Secreted heat soluble protein acting as a molecular shield in water-deficient condition (PubMed:22937162). Tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance by forming non-crystalline amorphous solids upon desiccation, and this vitrified state mirrors their protective capabilities (By similarity).[UniProtKB:P0CU39]<ref>PMID:22937162</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Upon stopping metabolic processes, some tardigrades can undergo anhydrobiosis. Secretory abundant heat-soluble (SAHS) proteins have been reported as candidates for anhydrobiosis-related proteins in tardigrades, which seem to protect extracellular components and/or secretory organelles. We determined structures of a SAHS protein from Ramazzottius varieornatus (RvSAHS1), which is one of the toughest tardigrades. RvSAHS1 shows a beta-barrel structure similar to fatty acid-binding proteins (FABPs), in which hydrophilic residues form peculiar hydrogen bond networks, which would provide RvSAHS1 with better tolerance against dehydration. We identified two putative ligand-binding sites: one that superimposes on those of some FABPs and the other, unique to and conserved in SAHS proteins. These results indicate that SAHS proteins constitute a new FABP family.
 
Structural insights into a secretory abundant heat-soluble protein from an anhydrobiotic tardigrade, Ramazzottius varieornatus.,Fukuda Y, Miura Y, Mizohata E, Inoue T FEBS Lett. 2017 Aug;591(16):2458-2469. doi: 10.1002/1873-3468.12752. Epub 2017, Aug 8. PMID:28703282<ref>PMID:28703282</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xna" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ramva]]
[[Category: Fukuda, Y]]
[[Category: Inoue, T]]
[[Category: Miura, Y]]
[[Category: Mizohata, E]]
[[Category: Fatty acid binding protein]]
[[Category: Lipid transport]]
[[Category: Ramazzottius varieornatus]]
[[Category: Ramazzottius varieornatus]]
[[Category: Secretary abundant heat soluble protein]]
[[Category: Fukuda Y]]
[[Category: Inoue T]]
[[Category: Miura Y]]
[[Category: Mizohata E]]
Retrieved from "https://proteopedia.org/5xna"