SAM-dependent methyltransferase: Difference between revisions

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<StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'>
<StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'>
== Function ==     
== Function ==     
'''SAM-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids.  SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation.  About 120 members of the SDM family have been identified.  They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S)<ref>PMID:23180741</ref>.  
'''SAM-dependent methyltransferase''' or '''S-adenosylmethionine-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids.  SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation.  About 120 members of the SDM family have been identified.  They differ in their substrate specificity and the atom targeted for methylation ('''N, O, C, S''')<ref>PMID:23180741</ref>.  
For '''Chemotaxis receptor methyltransferase CheR''' see details in [[Molecular Playground/CheR]].<ref>PMID:9628482</ref>.<br />
For '''Chemotaxis receptor methyltransferase CheR''' see details in [[Molecular Playground/CheR]].<ref>PMID:9628482</ref>.<br />
*SEE ALSO [[Chemotaxis protein]].
*SEE ALSO [[Chemotaxis protein]].
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== Structural highlights ==
== Structural highlights ==
The <scene name='51/510230/Cv/5'>core of the SDM fold contains alternating β strands and α helices</scene>.  SDM <scene name='51/510230/Cv/6'>active site is located between the 2 monomers</scene><ref>PMID:20876132</ref>. Water molecules are shown as red spheres.  
The <scene name='51/510230/Cv/5'>core of the SDM fold contains alternating β strands and α helices</scene>.  SDM <scene name='51/510230/Cv/6'>active site is located between the 2 monomers</scene><ref>PMID:20876132</ref>. Water molecules are shown as red spheres.  
</StructureSection> 


==3D structures of SAM-dependent methyltrasferase==
==3D structures of SAM-dependent methyltrasferase==
[[SAM-dependent methyltrasferase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>   
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*SAM-dependent O-methyltransferase
 
**[[1o54]] – TmSDM – ''Thermotoga maritima''<br />
**[[2hnk]] – SDM – ''Leptospira interrogans''<br />
**[[3r3h]] – SDM – ''Legionella pneumophila''<br />
**[[4qvk]] – PaSDM – ''Podospora anserina''<br />
**[[4ymg]] – PaSDM + SAM<br />
**[[4ymh]] – PaSDM + SAH<br />
**[[3ssm]], [[3sso]] – MgSDM + SAH – ''Micromonospora griseorubida''<br />
**[[3ssn]] – MgSDM + SAH + mycinamin <br />
 
*SAM-dependent N-methyltransferase
 
**[[1vlm]] – TmSDM (mutant)
 
*SAM-dependent C-methyltransferase
 
**[[4m72]] – ShSDM  – ''Streptomyces hygroscopicus''<br />
**[[4m73]], [[4m74]] – ShSDM (mutant) <br />
**[[4kib]] – ShSDM + SAH + methylphenylpyruvate <br />
**[[4kic]] – ShSDM + SAM + phenylpyruvate <br />
**[[4kif]], [[4kig]] – ShSDM + phenylpyruvate <br />
**[[4m6x]], [[4m6y]], [[4m71]] – ShSDM (mutant) + SAH + methylphenylpyruvate <br />
**[[5o4h]] – MmHCGC + SAM + pyridinol - ''Methanococcus maripaludis'' <br />
**[[5o4n]], [[5o4j]], [[5o4m]] – MmHCGC + SAH + pyridinol <br />
 
*SAM-dependent methyltransferase
 
**[[1wzn]] – SDM – ''Pyrococcus horikoshii''<br />
**[[2igt]] – SDM –'' Agrobacterium tumefaciens''<br />
**[[3cgg]] – CgSDM – ''Corynebacterium glutamicum''<br />
**[[3d2l]] - SDM – ''Exiguobacterium sibiricum''<br />
**[[3dh0]] - SDM – ''Aquifex aeolicus''<br />
**[[3dp7]] - SDM – ''Bacterioides vulgatus''<br />
**[[3ggd]] - SDM – ''Anabaena variabilis''<br />
**[[3sm3]] - SDM (mutant) – ''Methanosarcina mazei''<br />
**[[3bkx]] – SDM – ''Lactobacillus casei''<br />
**[[3kr9]] – SpSDM – ''Streptococcus pneumonia''<br />
 
*SAM-dependent methyltransferase complex with SAM/SAH
 
**[[3ku1]] – SpSDM + SAM<br />
**[[3lga]] – PaSDM + SAH – ''Pyrococcus abyssi''<br />
**[[3mb5]] – PaSDM + SAM<br />
**[[3ou2]] – SlSDM + SAH – ''Streptomyces luridus''<br />
**[[3ou6]] – SlSDM + SAM<br />
**[[3ou7]] – SlSDM + SAM + phosphonic acid derivative<br />
**[[5gm1]] – SbSDM + SAH – ''Streptomyces blastmyceticus''<br />
**[[5gm2]] – SbSDM + SAH + teleocidin<br />
**[[4x3q]] – SDM + SAH – ''Streptosporangium sibiricum''<br />
**[[3h2b]] – CgSDM + pyrophosphate + SAH<br />
**[[5bp7]] – SlSDM + SAH – ''Geobacter sulfurreducens''<br />
**[[5epe]] – SDM + SAH –'' Thiobacillus denitrificans''<br />
**[[5bp9]] – SDM + SAH – ''Bacterioides fragilis''<br />
**[[2ybo]] – PsaSDM + SAH – ''Pseudomonas aeruginosa'' <br />
**[[2ybq]] – PsaSDM + SAH + uroporphyrinogen <br />
   
*Chemotaxis receptor methyltransferase (CheR)


**[[1af7]] – StCheR – ''Salmonella typhimurium''<br />
**[[1bc5]] – StCheR + chemotaxis receptor peptide
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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