RNase P: Difference between revisions
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[[Image:6ah3_labeled_solid.png|left|400px]] | [[Image:6ah3_labeled_solid.png|left|400px]] | ||
== Function == | == Function == | ||
'''RNase P''' | '''RNase P''' is a [[Ribonuclease|ribonuclease]] that processes the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein (RNP) complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref><ref>PMID:25780121</ref> | ||
In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | ||
Sydney Altman shared in the 1989 Nobel Prize for his work on the catalytic properties of the RNP-based RNase P, as described [[ | Sydney Altman shared in the 1989 Nobel Prize for his work on the catalytic properties of the RNP-based RNase P, as described [[RNase P Nobel Prizes|here]]. | ||
== Structural insights == | == Structural insights == | ||
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Articles in Proteopedia concerning'''RNase P''' include: | Articles in Proteopedia concerning '''RNase P''' include: | ||
* A topic page on the RNP-based ''S. cerevisiae'' RNase P is found [[yeast RNase P|here]] | * A topic page on the RNP-based ''S. cerevisiae'' RNase P is found [[yeast RNase P|here]] | ||
</StructureSection> | </StructureSection> | ||
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==See Also== | ==See Also== | ||
*[[Ribozyme]] | |||
*[[Transfer RNA (tRNA)]] | *[[Transfer RNA (tRNA)]] | ||
*[[Ribosome|The Ribosome]] | *[[Ribosome|The Ribosome]] | ||
*[[Ribonuclease]] | |||
== References == | == References == | ||
