2ve3: Difference between revisions

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==Retinoic acid bound cyanobacterial CYP120A1==
The line below this paragraph, containing "STRUCTURE_2ve3", creates the "Structure Box" on the page.
<StructureSection load='2ve3' size='340' side='right'caption='[[2ve3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ve3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VE3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
{{STRUCTURE_2ve3|  PDB=2ve3  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ve3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ve3 OCA], [https://pdbe.org/2ve3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ve3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ve3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ve3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP120_SYNY3 CP120_SYNY3]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ve3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ve3 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structures of substrate-free and all- trans-retinoic acid-bound CYP120A1 from Synechocystis sp. PCC 6803 were determined at 2.4 and 2.1 A resolution, respectively, representing the first structural characterization of a cyanobacterial P450. Features of CYP120A1 not observed in other P450 structures include an aromatic ladder flanking the channel leading to the active site and a triple-glycine motif within SRS5. Using spectroscopic methods, CYP120A1 is shown to bind 13- cis-retinoic acid, 9- cis-retinoic acid, and retinal with high affinity and dissociation constants of less than 1 microM. Metabolism of retinoic acid by CYP120A1 suggests that CYP120A1 hydroxylates a variety of retinoid derivatives in vivo. On the basis of the retinoic acid-bound CYP120A1 crystal structure, we propose that either carbon 2 or the methyl groups (C16 or C17) of the beta-ionone ring are modified by CYP120A1.


'''RETINOIC ACID BOUND CYANOBACTERIAL CYP120A1'''
Crystal Structures of Substrate-Free and Retinoic Acid-Bound Cyanobacterial Cytochrome P450 CYP120A1.,Kuhnel K, Ke N, Cryle MJ, Sligar SG, Schuler MA, Schlichting I Biochemistry. 2008 May 31. PMID:18512957<ref>PMID:18512957</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2VE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE3 OCA].
<div class="pdbe-citations 2ve3" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Synechocystis sp.]]
<references/>
[[Category: Ke, N.]]
__TOC__
[[Category: Kuhnel, K.]]
</StructureSection>
[[Category: Schlichting, I.]]
[[Category: Large Structures]]
[[Category: Schuler, M A.]]
[[Category: Synechocystis sp. PCC 6803]]
[[Category: Sligar, S G.]]
[[Category: Ke N]]
[[Category: Heme]]
[[Category: Kuhnel K]]
[[Category: Iron]]
[[Category: Schlichting I]]
[[Category: Metal-binding]]
[[Category: Schuler MA]]
[[Category: Monooxygenase]]
[[Category: Sligar SG]]
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:23:33 2008''

Latest revision as of 17:30, 8 September 2026

Retinoic acid bound cyanobacterial CYP120A1

2ve3, resolution 2.10Å

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