6udt: Difference between revisions
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==X-ray co-crystal structure of compound 10 bound to human Mcl-1== | |||
<StructureSection load='6udt' size='340' side='right'caption='[[6udt]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6udt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UDT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q4V:(4S,7aR,9aR,10S,11E,18R)-6-chloro-10,18-dihydroxy-15-methyl-16-oxo-3,4,7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1-naphthalene]-18-carboxylic+acid'>Q4V</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6udt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6udt OCA], [https://pdbe.org/6udt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6udt RCSB], [https://www.ebi.ac.uk/pdbsum/6udt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6udt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Huang | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Huang X]] | |||
[[Category: Whittington D]] | |||
Latest revision as of 14:56, 13 March 2024
X-ray co-crystal structure of compound 10 bound to human Mcl-1
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