2c74: Difference between revisions

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<StructureSection load='2c74' size='340' side='right'caption='[[2c74]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2c74' size='340' side='right'caption='[[2c74]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c74]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C74 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c74]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C74 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c63|2c63]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c74 OCA], [https://pdbe.org/2c74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c74 RCSB], [https://www.ebi.ac.uk/pdbsum/2c74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c74 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c74 OCA], [http://pdbe.org/2c74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c74 RCSB], [http://www.ebi.ac.uk/pdbsum/2c74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c74 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433F_HUMAN 1433F_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<ref>PMID:12177059</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c74_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c74_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Synthetic construct]]
[[Category: Doyle, D A]]
[[Category: Arrowsmith C]]
[[Category: Edwards, A]]
[[Category: Doyle DA]]
[[Category: Elkins, J M]]
[[Category: Edwards A]]
[[Category: Johansson, C]]
[[Category: Elkins JM]]
[[Category: Smee, C E.A]]
[[Category: Johansson C]]
[[Category: Sundstrom, M]]
[[Category: Smee CEA]]
[[Category: Weigelt, J]]
[[Category: Sundstrom M]]
[[Category: Yang, X]]
[[Category: Weigelt J]]
[[Category: 14-3-3]]
[[Category: Yang X]]
[[Category: Phosphorylation]]
[[Category: Phosphoserine]]
[[Category: Signaling protein-peptide complex]]
Retrieved from "https://proteopedia.org/2c74"