6l2r: Difference between revisions

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New page: '''Unreleased structure''' The entry 6l2r is ON HOLD Authors: Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L. Description: Structural basis for conformational change upon ...
 
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'''Unreleased structure'''


The entry 6l2r is ON HOLD
==IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_E195S==
<StructureSection load='6l2r' size='340' side='right'caption='[[6l2r]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6l2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L2R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2r OCA], [https://pdbe.org/6l2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2r RCSB], [https://www.ebi.ac.uk/pdbsum/6l2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ILVC_STRP2 ILVC_STRP2] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]


Authors: Gyuhee, K., Donghyuk, S., Sumin, L., Jaesook, Y., Sangho, L.
==See Also==
 
*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
Description: Structural basis for conformational change upon binding to cofactors of IlvC, ketol-acid reductoisomerase, from Streptococcus pneumoniae
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Sangho, L]]
[[Category: Large Structures]]
[[Category: Sumin, L]]
[[Category: Streptococcus pneumoniae D39]]
[[Category: Jaesook, Y]]
[[Category: Donghyuk S]]
[[Category: Gyuhee, K]]
[[Category: Gyuhee K]]
[[Category: Donghyuk, S]]
[[Category: Jaesook Y]]
[[Category: Sangho L]]
[[Category: Sumin L]]
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