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==Cryo-EM structure of the translocator of the outer mitochondrial membrane==
==Cryo-EM structure of the translocator of the outer mitochondrial membrane==
<StructureSection load='6jnf' size='340' side='right'caption='[[6jnf]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
<SX load='6jnf' size='340' side='right' viewer='molstar' caption='[[6jnf]], [[Resolution|resolution]] 3.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6jnf]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JNF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6jnf]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JNF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=46E:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADECANOYLOXY)PROPYL+TETRADECANOATE'>46E</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.81&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnf OCA], [http://pdbe.org/6jnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jnf RCSB], [http://www.ebi.ac.uk/pdbsum/6jnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnf ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=46E:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADECANOYLOXY)PROPYL+TETRADECANOATE'>46E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jnf OCA], [https://pdbe.org/6jnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jnf RCSB], [https://www.ebi.ac.uk/pdbsum/6jnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jnf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TOM5_YEAST TOM5_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.<ref>PMID:9217162</ref>  [[http://www.uniprot.org/uniprot/TOM40_YEAST TOM40_YEAST]] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:10427088</ref> [[http://www.uniprot.org/uniprot/TOM22_YEAST TOM22_YEAST]] Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.<ref>PMID:10519552</ref> <ref>PMID:11276259</ref> <ref>PMID:7760834</ref>  [[http://www.uniprot.org/uniprot/TOM7_YEAST TOM7_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM7 is involved in assembly and stability of the TOM complex.<ref>PMID:11276259</ref>  [[http://www.uniprot.org/uniprot/TOM6_YEAST TOM6_YEAST]] Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex.<ref>PMID:11276259</ref> 
[https://www.uniprot.org/uniprot/TOM40_YEAST TOM40_YEAST] Channel-forming protein essential for import of protein precursors into mitochondria.<ref>PMID:10427088</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Araiso, Y]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Endo, T]]
[[Category: Araiso Y]]
[[Category: Kawano, S]]
[[Category: Endo T]]
[[Category: Kikkawa, M]]
[[Category: Kawano S]]
[[Category: Suzuki, J]]
[[Category: Kikkawa M]]
[[Category: Tsutsumi, A]]
[[Category: Suzuki J]]
[[Category: Yunoki, K]]
[[Category: Tsutsumi A]]
[[Category: Alpha/beta translocator]]
[[Category: Yunoki K]]
[[Category: Membrane protein complex]]
[[Category: Mitochondria]]
[[Category: Protein import]]
[[Category: Translocase]]

Latest revision as of 10:38, 27 March 2024

Cryo-EM structure of the translocator of the outer mitochondrial membrane

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