6q6f: Difference between revisions
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<StructureSection load='6q6f' size='340' side='right'caption='[[6q6f]], [[Resolution|resolution]] 3.30Å' scene=''> | <StructureSection load='6q6f' size='340' side='right'caption='[[6q6f]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6q6f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6F OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6q6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q6F FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HJQ:(2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine'>HJQ</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HJQ:(2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine'>HJQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6f OCA], [https://pdbe.org/6q6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q6f RCSB], [https://www.ebi.ac.uk/pdbsum/6q6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6q6f" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6q6f" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Araujo Cruz MM]] | ||
[[Category: | [[Category: Chaturvedi A]] | ||
[[Category: Ganser | [[Category: Ganser A]] | ||
[[Category: Goerlich | [[Category: Goerlich K]] | ||
[[Category: Goparaju | [[Category: Goparaju R]] | ||
[[Category: Gupta | [[Category: Gupta C]] | ||
[[Category: Heuser | [[Category: Heuser M]] | ||
[[Category: Kloos | [[Category: Kloos A]] | ||
[[Category: Kluenemann | [[Category: Kluenemann T]] | ||
[[Category: Preller | [[Category: Preller M]] | ||
[[Category: Schottmann | [[Category: Schottmann R]] | ||
[[Category: Struys | [[Category: Struys EA]] | ||
