6upt: Difference between revisions
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==Tudor Domain of Tumor suppressor p53BP1 with MFP-2706== | |||
<StructureSection load='6upt' size='340' side='right'caption='[[6upt]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6upt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UPT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QFM:2-((2-chlorobenzyl)thio)-4,5-dihydro-1H-imidazole'>QFM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6upt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6upt OCA], [https://pdbe.org/6upt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6upt RCSB], [https://www.ebi.ac.uk/pdbsum/6upt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6upt ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Brown PJ]] | |||
[[Category: Doak B]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Gunzburg M]] | |||
[[Category: Headey S]] | |||
[[Category: James LI]] | |||
[[Category: The J]] | |||
Latest revision as of 07:56, 11 October 2023
Tudor Domain of Tumor suppressor p53BP1 with MFP-2706
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