6urg: Difference between revisions
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New page: '''Unreleased structure''' The entry 6urg is ON HOLD Authors: Sun, Y., Zhang, Y., Walz, T., Tong, L. Description: Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex [[... |
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==Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex== | |||
<SX load='6urg' size='340' side='right' viewer='molstar' caption='[[6urg]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6urg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6URG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6urg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urg OCA], [https://pdbe.org/6urg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6urg RCSB], [https://www.ebi.ac.uk/pdbsum/6urg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6urg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref> | |||
==See Also== | |||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Tong | </SX> | ||
[[Category: Walz | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Sun Y]] | |||
[[Category: Tong L]] | |||
[[Category: Walz T]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 08:47, 4 June 2025
Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex
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